Ashton-Chess Joanna, Brouard Sophie, Soulillou Jean-Paul
INSERM U643/ITERT, Nantes, France.
Transpl Int. 2006 Jul;19(7):539-48. doi: 10.1111/j.1432-2277.2006.00339.x.
Tolerance to allografts would mean a better quality of life and prognosis for transplant patients. Despite the first descriptions of tolerance to alloantigens over 50 years ago, deliberately induced tolerance in the clinic on a wide scale remains a goal that is not quite in reach. However, much progress has been made in understanding tolerance in rodent models and in the few reports of induced or spontaneously occurring tolerance in humans. Here, we review this progress made in the quest to achieve clinical tolerance.
对同种异体移植物的耐受将意味着移植患者有更高的生活质量和更好的预后。尽管50多年前就首次描述了对同种异体抗原的耐受，但在临床上大规模地刻意诱导耐受仍然是一个尚未完全实现的目标。然而，在理解啮齿动物模型中的耐受以及人类诱导或自发出现耐受的少数报告方面已经取得了很大进展。在此，我们回顾在实现临床耐受的探索中所取得的这一进展。
