Yang Xing, Li Li-Ren, Pan Zhi-Zhon, Zhou Zhi-Wei, Wan De-Sen
State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China.
Ai Zheng. 2006 Jun;25(6):749-52.
BACKGROUND & OBJECTIVE: The prognosis of patients diagnosed with Dukes' B rectal carcinoma varies largely. Micrometastasis via lymphatic vessel may have occurred in Dukes' B rectal carcinoma although no clinical pathologic evidence of lymph node metastasis was found. This study was to investigate the correlation of lymphatic vessel density (LVD) to the prognosis of Dukes' B rectal carcinoma.
Immunohistochemistry was used to display the lymphatic vessels with lymphatic endothelium-specific marker, lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), in 54 specimens from Dukes' B rectal carcinoma. LVD in tumor, peri-tumor and normal tissues was calculated. All patients had complete clinical and follow-up data.
Of the 54 specimens, 11 (20.4%) were LYVE-1-negative in tumor, peri-tumor, and normal tissues, 43 (79.6%) were LYVE-1-positive. LVD was significantly higher in peri-tumor than in tumor and normal tissues (6.05+/-5.61 vs. 0.89+/-0.66 and 4.11+/-3.29, P<0.05), and was significantly lower in tumor than in normal tissues (P<0.05). No significant correlation was found between LVD and recurrence rate (P>0.05), or overall survival (P>0.05).
Lymphangiogenesis may occur in peri-tumor tissues. LVD may not be a prognostic factor of Dukes' B rectal carcinoma.
Dukes' B期直肠癌患者的预后差异很大。尽管未发现淋巴结转移的临床病理证据，但Dukes' B期直肠癌可能已发生通过淋巴管的微转移。本研究旨在探讨淋巴管密度（LVD）与Dukes' B期直肠癌预后的相关性。
采用免疫组织化学方法，用淋巴管内皮特异性标志物淋巴管内皮透明质酸受体-1（LYVE-1）显示54例Dukes' B期直肠癌标本中的淋巴管。计算肿瘤、肿瘤周围和正常组织中的LVD。所有患者均有完整的临床和随访数据。
54例标本中，11例（20.4%）肿瘤、肿瘤周围和正常组织LYVE-1阴性，43例（79.6%）LYVE-1阳性。肿瘤周围组织的LVD显著高于肿瘤组织和正常组织（6.05±5.61对0.89±0.66和4.11±3.29，P<0.05），肿瘤组织的LVD显著低于正常组织（P<0.05）。LVD与复发率（P>0.05）或总生存率（P>0.05）之间未发现显著相关性。
肿瘤周围组织可能发生淋巴管生成。LVD可能不是Dukes' B期直肠癌的预后因素。
