Niinimäki Maarit, Jouppila Pentti, Martikainen Hannu, Talvensaari-Mattila Anne
Department of Gynecology and Obstetrics, Oulu University Hospital, Oulu, Finland.
Fertil Steril. 2006 Aug;86(2):367-72. doi: 10.1016/j.fertnstert.2005.12.072. Epub 2006 Jun 9.
To compare the efficacy of the medical treatment to surgical uterine evacuation and patient satisfaction in each group.
A randomized, controlled study.
An outpatient clinic in the Department of Gynecology and Obstetrics in Oulu University Hospital, Oulu, Finland.
PATIENT(S): Ninety-eight eligible women who had had miscarriages.
INTERVENTION(S): Medical treatment of miscarriage (n = 49) with 200 mg of mifepristone and 0.8 mg of misoprostol 1-3 days after the event or surgical uterine evacuation (n = 49). Questionnaires to collect data of experienced pain and patient satisfaction.
MAIN OUTCOME MEASURE(S): The complete abortion rate with the primary treatment (primary outcome) and the patient satisfaction (secondary outcome).
RESULT(S): The success rate was equal (100% in surgical and 90% in medical group). More infections were diagnosed in the surgical group. Surgically treated patients were more satisfied with the treatment (100% vs. 88%). Medical treatment was considered more painful and fewer patients (70% vs. 91%) would choose the medical method in the future.
CONCLUSION(S): Medical treatment is an effective alternative to surgical treatment and increases the choice available to women. Surgical treatment is associated with more infections. More medically treated patients experienced pain and dissatisfaction.
比较药物治疗与手术清宫的疗效以及每组患者的满意度。
一项随机对照研究。
芬兰奥卢大学医院妇产科门诊。
98例符合条件的流产女性。
流产后1 - 3天采用200毫克米非司酮和0.8毫克米索前列醇进行药物流产治疗（n = 49）或手术清宫（n = 49）。通过问卷调查收集疼痛体验和患者满意度数据。
初始治疗的完全流产率（主要指标）和患者满意度（次要指标）。
成功率相同（手术组为100%，药物组为90%）。手术组诊断出更多感染病例。接受手术治疗的患者对治疗更满意（100%对88%）。药物治疗被认为更疼痛，未来选择药物治疗方法的患者更少（70%对91%）。
药物治疗是手术治疗的有效替代方法，增加了女性的选择。手术治疗与更多感染相关。更多接受药物治疗的患者经历了疼痛和不满。
