Tang Oi Shan, Ho Pak Chung
Department of Obstetrics and Gynaecology, The University of Hong Kong, Hong Kong SAR, China.
Curr Opin Obstet Gynecol. 2006 Dec;18(6):581-6. doi: 10.1097/GCO.0b013e32800feedb.
This paper reviews the current management of early pregnancy failure with particular emphasis on the use of misoprostol.
Medical management using misoprostol is effective for the management of miscarriages. The success rate ranged from 84 to 93% depending on the regimen of misoprostol, the duration of waiting period and the types of miscarriage.
Miscarriages occur in 10 to 20% of all pregnancies. Surgical evacuation has been used to empty the uterus. Recently, medical treatment using misoprostol has been studied for the management of miscarriage. It avoids surgery and its associated complications. Compared to expectant management, the success rate is higher. Nonsurgical management takes a longer period to reach the endpoint and medical management is associated with side effect of medication. Studies have shown that medical management is safe and acceptable to women. The optimal regimen of medical management, however, is yet to be determined.
本文回顾了早期妊娠失败的当前管理方法，特别强调米索前列醇的使用。
使用米索前列醇进行药物管理对流产的处理有效。成功率根据米索前列醇的用药方案、等待期的长短以及流产类型的不同，在84%至93%之间。
流产发生在所有妊娠的10%至20%。手术清宫一直被用于清空子宫。最近，使用米索前列醇进行药物治疗已被研究用于流产的管理。它避免了手术及其相关并发症。与期待治疗相比，成功率更高。非手术管理达到终点所需时间更长，且药物管理伴有药物副作用。研究表明，药物管理对女性来说是安全且可接受的。然而，药物管理的最佳方案尚未确定。
