Fletcher Lynda, Muschel Ruth J
Department of Pathology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Cancer Lett. 2006 Nov 8;243(1):1-8. doi: 10.1016/j.canlet.2006.01.006. Epub 2006 Jun 9.
The centrosome, the microtubule-organizing center of the cell, acts as a localization point, where signaling molecules are able to interact. Many kinases and phosphatases critical for regulation of DNA damage signaling pathways localize to the centrosome. This review will discuss the possible involvement of the centrosome in mediating DNA damage checkpoint control, in particular the effect of DNA damage signaling pathways involved in initiation or maintenance of cell cycle arrest on the centrosome. The mechanisms that lead to centrosome abnormalities such as centrosome hyperamplification and multipolarity in response to DNA damage will also be addressed.
中心体作为细胞的微管组织中心，充当信号分子能够相互作用的定位点。许多对DNA损伤信号通路调节至关重要的激酶和磷酸酶定位于中心体。本综述将讨论中心体在介导DNA损伤检查点控制中的可能作用，特别是参与细胞周期停滞起始或维持的DNA损伤信号通路对中心体的影响。还将探讨导致中心体异常（如响应DNA损伤时的中心体过度扩增和多极性）的机制。
