Nouws Henri P A, Delerue-Matos Cristina, Barros Aquiles A, Rodrigues José A
REQUIMTE, Instituto Superior de Engenharia do Porto, Rua Dr. António Bernardino de Almeida 431, 4200-072 Porto, Portugal.
J Pharm Biomed Anal. 2006 Sep 26;42(3):341-6. doi: 10.1016/j.jpba.2006.04.015. Epub 2006 Jun 9.
Electroanalytical methods based on square-wave adsorptive-stripping voltammetry (SWAdSV) and flow-injection analysis with SWAdSV detection (FIA-SWAdSV) were developed for the determination of paroxetine (PRX). The methods were based on the reduction of PRX at a mercury drop electrode at -1.55V versus Ag/AgCl, in a borate buffer of pH 8.8, and the possibility of accumulating the compound at the electrode surface. Because the presence of dissolved oxygen did not interfere significantly with the analysis, it was also possible to determine PRX using FIA-SWAdSV. This method enables analysis of up to 120 samples per hour at reduced costs. Both methods developed were validated and successfully applied to the quantification of PRX in pharmaceutical products.
开发了基于方波吸附溶出伏安法（SWAdSV）和流动注射分析-方波吸附溶出伏安检测法（FIA-SWAdSV）的电分析方法用于测定帕罗西汀（PRX）。这些方法基于在pH 8.8的硼酸盐缓冲液中，相对于Ag/AgCl，PRX在汞滴电极上于-1.55V处的还原，以及该化合物在电极表面富集的可能性。由于溶解氧的存在对分析干扰不大，因此也可以使用FIA-SWAdSV测定PRX。该方法能够以较低成本每小时分析多达120个样品。所开发的两种方法均经过验证，并成功应用于药品中PRX的定量分析。
