Marikawa Yusuke
Department of Anatomy, Biochemistry and Physiology, Institute for Biogenesis Research, University of Hawaii John A. Burns School of Medicine, 651 Ilalo Street, Honolulu, 96813, USA.
Semin Cell Dev Biol. 2006 Apr;17(2):175-84. doi: 10.1016/j.semcdb.2006.04.003. Epub 2006 Apr 25.
Wnt/beta-catenin signaling plays fundamental roles in body patterning in many invertebrate and vertebrate species, by acting as a key regulator of germ layer and body axis specification. This article focuses on the roles of Wnt/beta-catenin signaling in mouse early embryos, which exhibit a unique mode of development compared to non-mammalian vertebrates. Current experimental evidence suggests that Wnt/beta-catenin signaling is not essential for patterning embryos before implantation. However, Wnt/beta-catenin signaling regulates critical developmental events after implantation, namely the patterning of visceral endoderm, the induction of primitive streak, and the formation of anterior neural ectoderm. While Wnt/beta-catenin signaling regulates the body axis formation in both mouse and frog, the mode of its action is significantly diverged between these two vertebrate species.
Wnt/β-连环蛋白信号通路在许多无脊椎动物和脊椎动物的身体模式形成中发挥着重要作用，它是胚层和身体轴规范的关键调节因子。本文重点关注Wnt/β-连环蛋白信号通路在小鼠早期胚胎中的作用，与非哺乳动物脊椎动物相比，小鼠早期胚胎具有独特的发育模式。目前的实验证据表明，Wnt/β-连环蛋白信号通路对于植入前胚胎的模式形成并非必不可少。然而，Wnt/β-连环蛋白信号通路在植入后调节关键的发育事件，即脏内胚层的模式形成、原条的诱导以及前神经外胚层的形成。虽然Wnt/β-连环蛋白信号通路在小鼠和青蛙中都调节身体轴的形成，但在这两种脊椎动物物种中其作用模式存在显著差异。
