Uva Maurizio G, Longo Antonio, Reibaldi Michele, Reibaldi Alfredo
Sezione di Oftalmologia, Dipartimento di Specialità Medico-Chirurgiche, Università di Catania, Italy.
Am J Ophthalmol. 2006 Jun;141(6):1158-60. doi: 10.1016/j.ajo.2006.01.050.
To investigate the effect of timolol-dorzolamide and timolol-pilocarpine fixed combinations on retrobulbar vessel blood flow.
Prospective, randomized, masked, crossover clinical trial.
Sixteen patients with primary open angle glaucoma, treated with timolol 0.5%, received timolol 0.5%-dorzolamide 2% and timolol 0.5%-pilocarpine 2% for four weeks each. Heart rate, blood pressure, intraocular pressure (IOP), and peak systolic (PSV) and end diastolic velocities (EDV) in ophthalmic, central retinal, and short posterior ciliary arteries were measured before and after each treatment, and resistivity index was calculated.
The IOP was reduced (P < .01) by timolol-dorzolamide and, more effectively, timolol-pilocarpine combinations. In central retinal artery, the end diastolic velocity was increased by the timolol-dorzolamide combination (P < .01), resulting in higher end diastolic velocity and lower resistivity index values (both P < .01) compared with the timolol-pilocarpine combination.
The timolol-dorzolamide combination increases the end diastolic velocity in central retinal artery, despite a lower intraocular pressure decrease, suggesting an effect on retinal circulation.
研究噻吗洛尔-多佐胺和噻吗洛尔-毛果芸香碱固定复方制剂对球后血管血流的影响。
前瞻性、随机、双盲、交叉临床试验。
16例使用0.5%噻吗洛尔治疗的原发性开角型青光眼患者，分别接受0.5%噻吗洛尔-2%多佐胺和0.5%噻吗洛尔-2%毛果芸香碱治疗，各为期4周。在每次治疗前后测量心率、血压、眼压（IOP）以及眼动脉、视网膜中央动脉和睫状后短动脉的收缩期峰值速度（PSV）和舒张末期速度（EDV），并计算阻力指数。
噻吗洛尔-多佐胺以及更有效的噻吗洛尔-毛果芸香碱复方制剂均可降低眼压（P <.01）。在视网膜中央动脉，噻吗洛尔-多佐胺复方制剂可使舒张末期速度增加（P <.01），与噻吗洛尔-毛果芸香碱复方制剂相比，舒张末期速度更高，阻力指数值更低（均P <.01）。
噻吗洛尔-多佐胺复方制剂虽降低眼压的效果较弱，但可增加视网膜中央动脉的舒张末期速度，提示其对视网膜循环有影响。
