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Update and critical appraisal of combined timolol and carbonic anhydrase inhibitors and the effect on ocular blood flow in glaucoma patients.噻吗洛尔与碳酸酐酶抑制剂联合应用的最新情况及批判性评价及其对青光眼患者眼血流的影响
Clin Ophthalmol. 2010 Apr 26;4:233-41. doi: 10.2147/opth.s6372.
2
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Curr Med Res Opin. 2010 Jun;26(6):1255-67. doi: 10.1185/03007991003738485.
3
[Innovative glaucoma therapy. Glaucoma therapy with topical carbonic anhydrase inhibitors].[创新性青光眼治疗。局部用碳酸酐酶抑制剂治疗青光眼]
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[Ocular pulse amplitude, intraocular pressure and beta blocker/carbonic anhydrase inhibition in combined therapy of primary open-angle glaucoma].[原发性开角型青光眼联合治疗中眼脉冲幅度、眼压与β受体阻滞剂/碳酸酐酶抑制作用]
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Topical carbonic anhydrase inhibitors: a new perspective in glaucoma therapy.局部碳酸酐酶抑制剂：青光眼治疗的新视角。
Optom Clin. 1992;2(4):97-112.
6
Pharmacological and ocular hypotensive properties of topical carbonic anhydrase inhibitors.局部碳酸酐酶抑制剂的药理及降眼压特性。
Prog Retin Eye Res. 2000 Jan;19(1):87-112. doi: 10.1016/s1350-9462(99)00006-3.
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The efficacy of dorzolamide, a topical carbonic anhydrase inhibitor, in combination with timolol in the treatment of patients with open-angle glaucoma and ocular hypertension.局部用碳酸酐酶抑制剂多佐胺与噻吗洛尔联合用于治疗开角型青光眼和高眼压症患者的疗效。
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The long-term safety and efficacy of brinzolamide 1.0% (azopt) in patients with primary open-angle glaucoma or ocular hypertension. The Brinzolamide Long-Term Therapy Study Group.1.0%布林佐胺（阿佐普特）用于原发性开角型青光眼或高眼压症患者的长期安全性和有效性。布林佐胺长期治疗研究组。
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Literature review and meta-analysis of topical carbonic anhydrase inhibitors and ocular blood flow.局部碳酸酐酶抑制剂与眼血流的文献综述及荟萃分析
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1
Topical carbonic anhydrase inhibitors and glaucoma in 2021: where do we stand?2021年局部碳酸酐酶抑制剂与青光眼：我们目前的情况如何？
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2
Effects of dorzolamide/timolol fixed combination on retrobulbar hemodynamics in pseudoexfoliative glaucoma.多佐胺/噻吗洛尔固定复方制剂对假性剥脱性青光眼球后血流动力学的影响
Kaohsiung J Med Sci. 2016 Jan;32(1):38-43. doi: 10.1016/j.kjms.2015.12.004. Epub 2016 Jan 23.
3
Comparison of intraocular pressure, blood pressure, ocular perfusion pressure and blood flow fluctuations during dorzolamide versus timolol add-on therapy in prostaglandin analogue treated glaucoma subjects.比较前列腺素类似物治疗的青光眼患者在使用多佐胺与噻吗洛尔联合治疗时的眼压、血压、眼灌注压和血流波动。
Pharmaceuticals (Basel). 2012 Mar 21;5(3):325-38. doi: 10.3390/ph5030325.

本文引用的文献

1
Test/Retest reproducibility of color Doppler imaging assessment of blood flow velocity in orbital vessels.眼血管彩色多谱勒成像评估血流速度的测试/再测试可重复性。
J Glaucoma. 1995 Aug;4(4):281-6.
2
Risk factors for glaucoma needing more attention.需要更多关注的青光眼危险因素。
Open Ophthalmol J. 2009 Sep 17;3:38-42. doi: 10.2174/1874364100903020038.
3
Predictors for visual field progression and the effects of treatment with dorzolamide 2% or brinzolamide 1% each added to timolol 0.5% in primary open-angle glaucoma.预测原发性开角型青光眼视野进展的因素以及在噻吗心安 0.5%中分别添加多佐胺 2%或布林佐胺 1%治疗的效果。
Acta Ophthalmol. 2010 Aug;88(5):541-52. doi: 10.1111/j.1755-3768.2009.01595.x. Epub 2009 Oct 2.
4
Visual function, optic nerve structure, and ocular blood flow parameters after 1 year of glaucoma treatment with fixed combinations.青光眼固定复方治疗1年后的视觉功能、视神经结构及眼血流参数
Eur J Ophthalmol. 2009 Sep-Oct;19(5):790-7. doi: 10.1177/112067210901900517.
5
Reproducibility of color Doppler imaging.
Graefes Arch Clin Exp Ophthalmol. 2009 Nov;247(11):1531-8. doi: 10.1007/s00417-009-1178-3.
6
A comparison of the long-term effects of dorzolamide 2% and brinzolamide 1%, each added to timolol 0.5%, on retrobulbar hemodynamics and intraocular pressure in open-angle glaucoma patients.2%多佐胺和1%布林佐胺分别与0.5%噻吗洛尔联合应用对开角型青光眼患者球后血流动力学和眼压的长期影响比较。
J Ocul Pharmacol Ther. 2009 Jun;25(3):239-48. doi: 10.1089/jop.2008.0114.
7
Literature review and meta-analysis of topical carbonic anhydrase inhibitors and ocular blood flow.局部碳酸酐酶抑制剂与眼血流的文献综述及荟萃分析
Surv Ophthalmol. 2009 Jan-Feb;54(1):33-46. doi: 10.1016/j.survophthal.2008.06.002.
8
Visual field progression in the Collaborative Initial Glaucoma Treatment Study the impact of treatment and other baseline factors.协作性初始青光眼治疗研究中的视野进展：治疗及其他基线因素的影响
Ophthalmology. 2009 Feb;116(2):200-7. doi: 10.1016/j.ophtha.2008.08.051. Epub 2008 Nov 18.
9
Effects of dorzolamide 2% added to timolol maleate 0.5% on intraocular pressure, retrobulbar blood flow, and the progression of visual field damage in patients with primary open-angle glaucoma: a single-center, 4-year, open-label study.2%多佐胺添加到0.5%马来酸噻吗洛尔中对原发性开角型青光眼患者眼压、球后血流及视野损害进展的影响：一项单中心、4年、开放标签研究
Clin Ther. 2008 Jun;30(6):1120-34. doi: 10.1016/j.clinthera.2008.06.006.
10
Intraocular pressure-lowering efficacy of brinzolamide 1%/timolol 0.5% fixed combination compared with brinzolamide 1% and timolol 0.5%.1%布林佐胺/0.5%噻吗洛尔固定复方与1%布林佐胺和0.5%噻吗洛尔相比降低眼压的疗效。
Ophthalmology. 2008 Oct;115(10):1728-34, 1734.e1-2. doi: 10.1016/j.ophtha.2008.04.011. Epub 2008 Jun 5.

噻吗洛尔与碳酸酐酶抑制剂联合应用的最新情况及批判性评价及其对青光眼患者眼血流的影响

Update and critical appraisal of combined timolol and carbonic anhydrase inhibitors and the effect on ocular blood flow in glaucoma patients.

作者信息

Moss Adam M, Harris Alon, Siesky Brent, Rusia Deepam, Williamson Kathleen M, Shoshani Yochai

机构信息

Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

出版信息

Clin Ophthalmol. 2010 Apr 26;4:233-41. doi: 10.2147/opth.s6372.

DOI:10.2147/opth.s6372
PMID:20463789
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2861928/
Abstract

Topical hypotensive therapy with both timolol and carbonic anhydrase inhibitors has been shown to be efficacious at reducing intraocular pressure. Many prospective studies have also suggested that carbonic anhydrase inhibitors augment ocular blood flow and vascular regulation independent of their hypotensive effects. Although consistent in their findings, these studies must be cautiously interpreted due to the limitations of study design and specific blood flow imaging modalities. The purpose of this review is to appraise and critically evaluate the current body of literature investigating the effects of combined treatment with topical carbonic anhydrase inhibitors and timolol in patients with glaucoma with respect to ocular blood flow, visual function, and optic nerve head structure.

摘要

噻吗洛尔和碳酸酐酶抑制剂的局部降压治疗已被证明在降低眼压方面是有效的。许多前瞻性研究还表明，碳酸酐酶抑制剂可增强眼部血流和血管调节，而与其降压作用无关。尽管这些研究结果一致，但由于研究设计和特定血流成像方式的局限性，对其解释必须谨慎。本综述的目的是评估和批判性评价目前关于青光眼患者联合使用局部碳酸酐酶抑制剂和噻吗洛尔治疗对眼部血流、视觉功能和视神经乳头结构影响的文献。