噻吗洛尔与碳酸酐酶抑制剂联合应用的最新情况及批判性评价及其对青光眼患者眼血流的影响
Update and critical appraisal of combined timolol and carbonic anhydrase inhibitors and the effect on ocular blood flow in glaucoma patients.
作者信息
Moss Adam M, Harris Alon, Siesky Brent, Rusia Deepam, Williamson Kathleen M, Shoshani Yochai
机构信息
Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
出版信息
Clin Ophthalmol. 2010 Apr 26;4:233-41. doi: 10.2147/opth.s6372.
Abstract
Topical hypotensive therapy with both timolol and carbonic anhydrase inhibitors has been shown to be efficacious at reducing intraocular pressure. Many prospective studies have also suggested that carbonic anhydrase inhibitors augment ocular blood flow and vascular regulation independent of their hypotensive effects. Although consistent in their findings, these studies must be cautiously interpreted due to the limitations of study design and specific blood flow imaging modalities. The purpose of this review is to appraise and critically evaluate the current body of literature investigating the effects of combined treatment with topical carbonic anhydrase inhibitors and timolol in patients with glaucoma with respect to ocular blood flow, visual function, and optic nerve head structure.
摘要
噻吗洛尔和碳酸酐酶抑制剂的局部降压治疗已被证明在降低眼压方面是有效的。许多前瞻性研究还表明，碳酸酐酶抑制剂可增强眼部血流和血管调节，而与其降压作用无关。尽管这些研究结果一致，但由于研究设计和特定血流成像方式的局限性，对其解释必须谨慎。本综述的目的是评估和批判性评价目前关于青光眼患者联合使用局部碳酸酐酶抑制剂和噻吗洛尔治疗对眼部血流、视觉功能和视神经乳头结构影响的文献。
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