人体视网膜体内光学相干断层扫描图像的组织学相关性
Histologic correlation of in vivo optical coherence tomography images of the human retina.
作者信息
Chen Teresa C, Cense Barry, Miller Joan W, Rubin Peter A D, Deschler Daniel G, Gragoudas Evangelos S, de Boer Johannes F
机构信息
Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, 02114, USA.
出版信息
Am J Ophthalmol. 2006 Jun;141(6):1165-8. doi: 10.1016/j.ajo.2006.01.086.
PURPOSE
To correlate in vivo human retina optical coherence tomography (OCT)3 images with histology.
DESIGN
Case series.
METHODS
Linear OCT3 scans through the macula and optic nerve were obtained in three eyes of three patients who then underwent exenteration surgery for orbital cancers. OCT3 images were then correlated with histology.
RESULTS
On histology, two eyes were normal, and one eye had dry macular degeneration. The plexiform layers on histology correlated with the green/yellow areas on the OCT3 scans, and the nuclear layers correlated with the black areas on the OCT3 scans.
CONCLUSIONS
The authors are unaware of previous reports correlating histology to in vivo human retina OCT3 images. Our findings using human eyes are not different from previous animal studies, in that the plexiform layers are optically highly backscattering and the nuclear layers are not.
目的
将人体视网膜光学相干断层扫描（OCT）3的体内图像与组织学进行关联。
设计
病例系列研究。
方法
对三名患者的三只眼睛进行了穿过黄斑和视神经的线性OCT3扫描，这些患者随后接受了眼眶癌的眼球摘除手术。然后将OCT3图像与组织学进行关联。
结果
组织学检查显示，两只眼睛正常，一只眼睛患有干性黄斑变性。组织学上的神经丛层与OCT3扫描上的绿色/黄色区域相关，而核层与OCT3扫描上的黑色区域相关。
结论
作者未发现之前有将组织学与人体视网膜OCT3体内图像进行关联的报道。我们在人眼上的研究结果与之前的动物研究并无差异，即神经丛层具有高度光学后向散射，而核层则不然。
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