Coccaro Emil F, Beresford Brendan, Minar Philip, Kaskow Jon, Geracioti Thomas
Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA.
J Psychiatr Res. 2007 Sep;41(6):488-92. doi: 10.1016/j.jpsychires.2006.04.009.
Studies of various species suggest that testosterone, assayed in various compartments, is correlated with aggression and possibly related behaviors. The objective of this study was to assess the relationship between cerebrospinal fluid testosterone (CSF TEST) and measures of aggression, impulsivity, and venturesomeness in male personality disordered subjects and test the hypothesis that CSF TEST would correlate directly with each measure in this group.
Lumbar CSF for morning basal levels of testosterone were obtained from 31 male subjects with personality disorder. Aggression was assessed dimensionally through the use of the life history of aggression (LHA) assessment, and categorically by the research diagnosis of intermittent explosive disorder. Impulsiveness and venturesomeness were assessed using the Eysenck personality questionnaire - II (EPQ-II).
CSF TEST did not correlate with measures of aggression or impulsivity but did correlate directly with venturesomeness (r = .42, p = .021). Adjusting for age and height modestly reduced the magnitude and statistical significance of this correlation.
In contrast to some published studies, CSF TEST was not found to have a significant relationship with aggression. The presence of a modest correlation between CSF TEST and venturesomeness, but not impulsivity, in male personality-disordered subjects suggests a possible relationship between CSF TEST and a type of sensation-seeking that involves consideration of the consequences of action taken.
对不同物种的研究表明，在不同腔室中检测到的睾酮与攻击性及可能相关的行为存在关联。本研究的目的是评估男性人格障碍受试者脑脊液睾酮（CSF TEST）与攻击性、冲动性和冒险性测量指标之间的关系，并检验CSF TEST与该组中每项测量指标直接相关的假设。
从31名患有人格障碍的男性受试者中获取用于检测早晨基础睾酮水平的腰椎脑脊液。通过使用攻击性生活史（LHA）评估从维度上评估攻击性，并通过间歇性爆发性障碍的研究诊断进行分类评估。使用艾森克人格问卷-II（EPQ-II）评估冲动性和冒险性。
CSF TEST与攻击性或冲动性测量指标无相关性，但与冒险性直接相关（r = 0.42，p = 0.021）。对年龄和身高进行校正后，该相关性的强度和统计学意义略有降低。
与一些已发表的研究不同，未发现CSF TEST与攻击性有显著关系。在男性人格障碍受试者中，CSF TEST与冒险性之间存在适度相关性，但与冲动性无关，这表明CSF TEST与一种涉及考虑所采取行动后果的寻求刺激类型之间可能存在关系。
