Geuna Stefano, Papalia Igor, Tos Pierluigi
Dipartimento di Scienze Cliniche e Biologiche, Università di Torino, Ospedale San Luigi, Regione Gonzole 10, Orbassano, TO, 10043, Italy.
Brain Res Rev. 2006 Sep;52(2):381-8. doi: 10.1016/j.brainresrev.2006.05.002.
The last 15 years have seen a growing interest regarding a technique for nerve repair named end-to-side (terminolateral) neurorrhaphy. This technique is based on the concept that nerve fiber regeneration along the distal stump of a transected nerve, the proximal stump of which was lost, can be obtained by just suturing the proximal end of its distal stump to the epinerium of a neighbor healthy and undamaged donor nerve. A large body of experimental studies have shown that end-to-side neurorrhaphy, in fact, is able to induce collateral sprouting from donor nerve's axons which is at the basis of the massive repopulation of the distal nerve stump. The regenerating nerve fibers eventually reinnervate the periphery of the severed nerve leading to a recovery of the lost function the degree of which varies depending on factors that still have to be elucidated. Surprisingly, this puzzling concept of nerve regeneration has attracted very little attention from basic neuroscientists so far and, thus, the present paper is intended to call for more biological research on it by overviewing the relevant literature and indicating the several unanswered questions that this concept asks to the neuroscience community.
在过去的15年里，一种名为端侧（端旁）神经缝合术的神经修复技术越来越受到关注。该技术基于这样一种概念：对于一条横断神经，其近端已缺失，通过将其远端残端的近端缝合到相邻健康且未受损的供体神经的神经外膜上，可实现神经纤维沿该横断神经远端残端的再生。大量实验研究表明，事实上，端侧神经缝合术能够诱导供体神经轴突的侧支芽生，这是远端神经残端大量重新神经支配的基础。再生的神经纤维最终重新支配离断神经的外周，导致丧失功能的恢复，恢复程度因仍有待阐明的因素而异。令人惊讶的是，这种令人费解的神经再生概念迄今为止很少受到基础神经科学家的关注，因此，本文旨在通过综述相关文献并指出该概念向神经科学界提出的几个未解决问题，呼吁对其进行更多的生物学研究。
