Castro Claudia Y
The University of Texas Medical Branch (UTMB), Department of Pathology, Galveston, TX 77555, USA.
Semin Thorac Cardiovasc Surg. 2006 Spring;18(1):13-9. doi: 10.1053/j.semtcvs.2006.02.001.
Diffuse alveolar damage (DAD) is the histologic correlate of most patients with adult respiratory distress syndrome (ARDS). It is a relatively straight forward diagnosis and the main differential diagnosis clinically is acute pneumonia and histologically is bronchiolitis obliterans and organizing pneumonia (BOOP). The histologic progression of DAD includes 3 phases (exudative, proliferative, and fibrotic) that correlate with the time rather than its specific cause. The factors that govern which patients will do well and which will develop a fulminant course is not known.
弥漫性肺泡损伤（DAD）是大多数成人呼吸窘迫综合征（ARDS）患者的组织学表现。这是一种相对直接的诊断，临床上主要的鉴别诊断是急性肺炎，组织学上是闭塞性细支气管炎伴机化性肺炎（BOOP）。DAD的组织学进展包括3个阶段（渗出期、增生期和纤维化期），这些阶段与时间相关，而非特定病因。目前尚不清楚哪些因素决定患者病情会好转，哪些会发展为暴发性病程。
