在志愿者中，毒扁豆碱控释后血浆毒扁豆碱浓度与乙酰胆碱酯酶抑制百分比随时间的相关性。
Correlation between plasma physostigmine concentrations and percentage of acetylcholinesterase inhibition over time after controlled release of physostigmine in volunteer subjects.
作者信息
Knapp S, Wardlow M L, Albert K, Waters D, Thal L J
机构信息
Department of Psychiatry, School of Medicine, University of California, San Diego.
出版信息
Drug Metab Dispos. 1991 Mar-Apr;19(2):400-4.
Five to six subjects ingested doses of controlled-release physostigmine salicylate tablets (9, 12, and 15 mg) followed by sequential blood drawing for measurement of plasma physostigmine concentrations and percentage of acetylcholinesterase (AChE) inhibition. Both plasma physostigmine concentrations and percentage of AChE inhibition demonstrated dose proportionality to three doses of ingested drug. Plasma physostigmine concentrations correlated with percentage of AChE inhibition across time by dose and across all doses and subjects tested. These data should be helpful to physicians in adjusting physostigmine dosing, enabling them to use the relatively simple and widely available AChE assay to approximate plasma physostigmine concentrations.
五到六名受试者服用了控释水杨酸毒扁豆碱片（9毫克、12毫克和15毫克），随后依次采血以测量血浆毒扁豆碱浓度和乙酰胆碱酯酶（AChE）抑制百分比。血浆毒扁豆碱浓度和AChE抑制百分比均显示与三种摄入药物剂量呈剂量比例关系。血浆毒扁豆碱浓度在不同时间、不同剂量以及所有测试的剂量和受试者中均与AChE抑制百分比相关。这些数据应有助于医生调整毒扁豆碱剂量，使他们能够使用相对简单且广泛可用的AChE检测方法来估算血浆毒扁豆碱浓度。
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