Thompson Jill M, Hamilton C J, Gray John M, Quinn J G, Mackin Paul, Young Allan H, Ferrier I Nicol
University of Newcastle-upon-Tyne, UK.
Memory. 2006 May;14(4):437-51. doi: 10.1080/09658210500464293.
Visuospatial working memory theory is used to interpret the cognitive impairment in euthymic bipolar disorder. Such patients show deficits in the Corsi Blocks Test (CBT) and executive control. To understand these deficits, 20 euthymic bipolar patients and controls were administered the CBT, Visual Patterns Test (VPT), and a new visual memory task designed to make minimal demands on executive resources. Initial analyses validated the visual memory task and implicated executive involvement in the CBT and VPT. Subsequent analyses on a number of tests confirmed CBT and executive deficits while performance was normal on the VPT and visual memory test. ANCOVA indicated that impaired executive function underpinned patients' CBT performance. Implications for the interface between executive and slave systems of working memory are discussed.
视觉空间工作记忆理论被用于解释处于心境正常期的双相情感障碍患者的认知损害。这类患者在Corsi方块测验(CBT)和执行控制方面表现出缺陷。为了解这些缺陷,对20名处于心境正常期的双相情感障碍患者和对照组进行了Corsi方块测验、视觉模式测验(VPT)以及一项旨在对执行资源需求最小化的新视觉记忆任务。初步分析验证了该视觉记忆任务,并表明执行功能参与了Corsi方块测验和视觉模式测验。随后对多项测试的分析证实了Corsi方块测验和执行功能缺陷,而视觉模式测验和视觉记忆测试的表现正常。协方差分析表明,执行功能受损是患者Corsi方块测验表现的基础。文中讨论了对工作记忆的执行系统和从属系统之间接口的影响。