银屑病治疗药物与葡萄糖-6-磷酸脱氢酶
Psoriatic therapeutics and glucose-6-phosphate dehydrogenase.
作者信息
Cotton D W, van Rossum E
出版信息
Arch Dermatol Forsch. 1975;252(2):147-9. doi: 10.1007/BF00561837.
PMID:167665
Abstract
The inhibitory effects of various agents on the enzyme glucose-6-phosphate dehydrogenase have been studied in vitro. Stress is laid on the calculation of kinetic parameters such as true K-I values. The most active inhibitor was methotrexate, closely followed by cGMP. The increase in inhibitory activity after incubation of methotrexate with liver slices is discussed.
摘要
已在体外研究了各种药剂对葡萄糖-6-磷酸脱氢酶的抑制作用。重点在于动力学参数的计算，如真实的K-I值。活性最高的抑制剂是甲氨蝶呤，其次是环磷酸鸟苷（cGMP）。讨论了甲氨蝶呤与肝切片孵育后抑制活性的增加。
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