Kumar Bhushan, Arora Sunil, Kumaran Muthu Sendhil, Jain Rajesh, Dogra Sunil
Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Indian J Dermatol Venereol Leprol. 2006 May-Jun;72(3):203-6. doi: 10.4103/0378-6323.25780.
To conduct a cross-sectional study to compare Dsg1 and Dsg3 antibody levels independently with severity of disease activity in pemphigus vulgaris (PV) and pemphigus foliaceus (PF).
Blood samples from 44 patients with pemphigus (PV-38, PF-6) were analyzed using ELISA. The severity of skin and mucosal disease was graded using a score from 0 to 3.
A statistically significant correlation between increase in Dsg 3 antibody titres with severity of oral involvement and Dsg 1 titres with severity of skin involvement was found in both PV and PF patients (p < 0.01). However, we were unable to demonstrate a relationship between increased titres of Dsg1 and Dsg 3 antibodies with oral and skin involvement respectively.
This study suggests that the severity of skin and oral disease in pemphigus is determined by the quantities of Dsg1 and Dsg3 antibodies respectively.
开展一项横断面研究，以独立比较寻常型天疱疮（PV）和落叶型天疱疮（PF）中桥粒芯糖蛋白1（Dsg1）和桥粒芯糖蛋白3（Dsg3）抗体水平与疾病活动严重程度的关系。
采用酶联免疫吸附测定（ELISA）法分析44例天疱疮患者（38例PV患者，6例PF患者）的血样。皮肤和黏膜疾病的严重程度采用0至3分的评分系统进行分级。
在PV和PF患者中均发现，Dsg 3抗体滴度升高与口腔受累严重程度之间以及Dsg 1滴度与皮肤受累严重程度之间存在统计学显著相关性（p < 0.01）。然而，我们未能证明Dsg1和Dsg 3抗体滴度升高分别与口腔和皮肤受累之间存在关联。
本研究表明，天疱疮患者皮肤和口腔疾病的严重程度分别由Dsg1和Dsg3抗体的量所决定。
