通过使用桥粒芯糖蛋白酶联免疫吸附测定改善越南寻常型天疱疮患者的治疗效果。
Improving Treatment Outcome of Pemphigus Vulgaris on Vietnamese Patients by Using Desmoglein Elisa Test.
作者信息
Van Anh Tran Thi, Nguyen Thuong Van, Huu Sau Nguyen, Thi Lan Pham, Minh Phuong Pham Thi, Huu NghiDinh, Cam Van Tran, Huyen My Le, Nguyet Minh Vu, Hau Khang Tran, Gandolfi Marco, Satolli Francesca, Feliciani Claudio, Tirant Michael, Vojvodic Aleksandra, Lotti Torello
机构信息
National Hospital of Dermatology and Venereology, Hanoi, Vietnam.
Unit of Dermatology, University of Parma, Parma, Italy.
出版信息
Open Access Maced J Med Sci. 2019 Jan 22;7(2):195-197. doi: 10.3889/oamjms.2019.003. eCollection 2019 Jan 30.
BACKGROUND
Pemphigus Vulgaris (PV) is a chronic disease, is characterized by the presence of flacid bullous in skin and mucosa. There are 2 main autoantibodies against desmoglein3 (Dsg3) and desmoglein1 (Dsg1).
AIM
The aims of this study were to evaluate the before and after treatment outcome with corticosteroid, using Desmoglein ELISA test.
METHOD
Forty patients with Pemphigus include 36 PV and 4 PF (28 women, 12 women) were enrolled. The titers of Dsg in pemphigus patients by using ELISA test were done before and 1-month treatment.
RESULTS
Both anti-Dsg1 and anti-Dsg3 levels were significantly reduced after treatment (P < 0.05). The severity of skin lesions was correlated with anti-Dsg1 antibody level and the severity of oral lesions was significantly correlated with anti-Dsg 3 antibody levels (p < 0.05).
CONCLUSION
It is recommended that we can predict and improve the outcome of treatment by using Desmoglein ELISA test.
背景
寻常型天疱疮（PV）是一种慢性疾病，其特征为皮肤和黏膜出现松弛性水疱。存在两种主要的针对桥粒芯糖蛋白3（Dsg3）和桥粒芯糖蛋白1（Dsg1）的自身抗体。
目的
本研究的目的是使用桥粒芯糖蛋白酶联免疫吸附测定（ELISA）试验评估皮质类固醇治疗前后的结果。
方法
纳入40例天疱疮患者，其中包括36例PV患者和4例增殖型天疱疮（PF）患者（28例女性，12例男性）。在治疗前及治疗1个月后，通过ELISA试验检测天疱疮患者的Dsg滴度。
结果
治疗后抗Dsg1和抗Dsg3水平均显著降低（P < 0.05）。皮肤病变的严重程度与抗Dsg1抗体水平相关，口腔病变的严重程度与抗Dsg3抗体水平显著相关（P < 0.05）。
结论
建议使用桥粒芯糖蛋白ELISA试验来预测和改善治疗结果。
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