Sözübir S, Ergun G, Celik A, Ulman I, Avanoglu A
Department of Pediatric Surgery, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
Minerva Urol Nefrol. 2006 Jun;58(2):207-12.
The aim of this paper was to examine the early morning spot urine osmolality and some other parameters easily detected from home chart recordings and history as predictive of the therapeutic response to desmopressin in children with monosymptomatic nocturnal enuresis.
Sixty seven monosymptomatic nocturnal enuretic children were included in the study. Age, sex, family history, the number of family members and siblings, existence of urgency symptoms, the history of urinary tract infection, sleep patterns, the number of wet nights per month and bedwetting in the same night were recorded. Additionally, spot morning urine osmolality was examined. All children were given desmopressin for at least 2 months. At the end of the treatment period, patients considered as responders and non-responders were compared in all these parameters.
Although there was considerable overlap between groups, lower spot urine osmolality was the only data we found statistically significant as predictive of response to desmopressin. Moreover, male predominance, fewer wet nights per month and bedwetting per night were also associated with a better response.
We believe that it is important to characterize such different subgroups that could be used as predictors of a good response to desmopressin.
本文旨在研究清晨随机尿渗透压以及一些可从家庭记录和病史中轻松获取的其他参数，以预测单纯性夜间遗尿症患儿对去氨加压素治疗的反应。
本研究纳入了67例单纯性夜间遗尿症患儿。记录其年龄、性别、家族史、家庭成员及兄弟姐妹数量、尿急症状的存在情况、尿路感染病史、睡眠模式、每月尿床次数以及同一晚尿床情况。此外，检测清晨随机尿渗透压。所有患儿均接受去氨加压素治疗至少2个月。治疗期结束时，对视为反应者和无反应者的所有这些参数进行比较。
尽管两组之间存在相当大的重叠，但较低的随机尿渗透压是我们发现的唯一具有统计学意义的预测对去氨加压素反应的数据。此外，男性占主导、每月尿床次数较少以及每晚尿床也与较好的反应相关。
我们认为，明确这些可作为对去氨加压素良好反应预测指标的不同亚组非常重要。
