Masoero G, Rossanino A, Arossa W, De la Pierre M
Department of Gastroenterology, Ospedale Mauriziano Umberto I, Torino, Italy.
J Clin Gastroenterol. 1991 Jun;13(3):291-5. doi: 10.1097/00004836-199106000-00008.
We evaluated the circadian pattern of gastric acidity by prolonged intraluminal pHmetry in 15 "responder" and 10 "nonresponder" duodenal ulcer patients after nocturnal administration of placebo, ranitidine, and famotidine. Acidity was measured during predefined periods under the different drug regimens in the two groups of subjects, and a comparison was performed both within and between groups. With placebo, significantly lower median 24-h pH values were detected in patients with resistant ulcer than in responders (1.13 versus 1.63). On the contrary, no statistical difference was detected between the two groups during any time of day after administration of either ranitidine or famotidine. Within each group, no significant difference was noted between the two different H2-blockers. Thus, our data suggest that patients with resistant duodenal ulcer display an increased gastric acidity in control conditions but a "normal" response to administration of antisecretory drugs.
我们通过长时间腔内pH测量法评估了15名“反应者”和10名“无反应者”十二指肠溃疡患者在夜间服用安慰剂、雷尼替丁和法莫替丁后胃酸的昼夜模式。在两组受试者不同药物治疗方案的预定义时间段内测量酸度，并在组内和组间进行比较。服用安慰剂时，耐药性溃疡患者的24小时pH中位数明显低于反应者（分别为1.13和1.63）。相反，服用雷尼替丁或法莫替丁后的任何时间段内，两组之间均未检测到统计学差异。在每组中，两种不同的H2受体阻滞剂之间未发现显著差异。因此，我们的数据表明，耐药性十二指肠溃疡患者在对照条件下胃酸度增加，但对抗分泌药物的给药表现出“正常”反应。
