Savarino V, Mela G S, Zentilin P, Scalabrini P, Bonifacino G, Gambaro P, Celle G
Istituto Scientifico di Medicina Interna, Università di Genova, Italia.
Digestion. 1989;42(1):1-6. doi: 10.1159/000199818.
The effects of single daily doses of placebo, nizatidine 300 mg, ranitidine 300 mg and famotidine 40 mg, given at 22.00 h, have been compared in 16 patients with healed duodenal ulcers. Each of them underwent the above treatment on four separate occasions. The three H2 receptor antagonists showed a significantly higher acid inhibition than placebo (p less than 0.003) throughout the whole 24-hour period. Famotidine turned out to be more effective than nizatidine (p less than 0.02) in reducing circadian acidity, while there was no difference between ranitidine and nizatidine. The effects of the three H2 blockers on overnight acidity (from 23.00 to 07.00) were similar to each other, whereas both famotidine (p less than 0.003) and ranitidine (p less than 0.02) produced more anacidity than nizatidine during the morning hours (from 07.00 to 12.00). The time period elapsed in consecutive minutes above 5.0 pH units during drug-related events was significantly longer with both famotidine (p less than 0.01) and ranitidine (p less than 0.01) compared to nizatidine. Therefore in the recommended dosages for clinical use the acid suppression of nizatidine was significantly shorter-lasting than that of both ranitidine and famotidine. The major change is represented by the lack of carryover effect of nizatidine on morning acidity.
在16例十二指肠溃疡已愈合的患者中，比较了每天22:00服用单剂量安慰剂、300毫克尼扎替丁、300毫克雷尼替丁和40毫克法莫替丁的效果。他们每个人在四个不同的时间段接受上述治疗。在整个24小时期间，三种H2受体拮抗剂的抑酸作用均显著高于安慰剂（p<0.003）。在降低昼夜酸度方面，法莫替丁比尼扎替丁更有效（p<0.02），而雷尼替丁和尼扎替丁之间没有差异。三种H2阻滞剂对夜间酸度（23:00至07:00）的影响彼此相似，而在上午时段（07:00至12:00），法莫替丁（p<0.003）和雷尼替丁（p<0.02）产生的无酸状态均比尼扎替丁更多。与尼扎替丁相比，在与药物相关的事件中，pH值高于5.0单位持续的连续分钟数，法莫替丁（p<0.01）和雷尼替丁（p<0.01）均显著更长。因此，在临床使用的推荐剂量下，尼扎替丁的抑酸作用持续时间明显短于雷尼替丁和法莫替丁。主要变化表现为尼扎替丁对早晨酸度缺乏延续效应。
