Marigo Mauro, Jørgensen Karl Anker
Danish National Research Foundation: Center for Catalysis, Department of Chemistry, Aarhus University, DK-8000 Aarhus C, Denmark.
Chem Commun (Camb). 2006 May 21(19):2001-11. doi: 10.1039/b517090g. Epub 2006 Jan 25.
The direct enantioselective introduction of a stereogenic carbon-heteroatom bond adjacent to a carbonyl functionality leads to optically active compounds of significant importance for e.g. the life-science industry. Organocatalytic enantioselective amination, oxygenation, fluorination, chlorination, bromination and sulfenylation of aldehydes and ketones, using chiral amines as the catalysts, are reviewed in this feature article. Furthermore, a few other transformations are also outlined. The scope, potential and application of these organocatalytic asymmetric reactions are presented and the mechanistic aspects discussed.
在羰基官能团相邻位置直接对映选择性引入立体ogenic碳-杂原子键可产生对生命科学行业等具有重要意义的光学活性化合物。本专题文章综述了使用手性胺作为催化剂对醛和酮进行有机催化对映选择性胺化、氧化、氟化、氯化、溴化和亚磺酰化反应。此外，还概述了其他一些转化反应。介绍了这些有机催化不对称反应的范围、潜力和应用，并讨论了其机理方面。
