Department of Chemistry , Rice University BioScience Research Collaborative , 6500 Main Street , Houston , Texas 77030 , United States.
J Am Chem Soc. 2019 Feb 13;141(6):2242-2246. doi: 10.1021/jacs.8b13818. Epub 2019 Feb 1.
An aza analogue of the Rubottom oxidation is reported. This facile transformation takes place at ambient temperature and directly converts silyl enol ethers to the corresponding primary α-aminoketones. The use of hexafluoroisopropanol (HFIP) as the solvent is essential for the success of this reaction. Overall this process is well-suited for the aza-functionalization and derivatization of complex organic molecules.
报道了 Rubottom 氧化的氮杂类似物。这种简便的转化在环境温度下进行，并直接将硅基烯醇醚转化为相应的伯α-氨基酮。使用六氟异丙醇（HFIP）作为溶剂对于该反应的成功至关重要。总的来说，该过程非常适合复杂有机分子的氮杂官能化和衍生化。
