• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

[实体瘤及血液肿瘤学治疗中的靶向治疗。进展与失望]

[Targeted therapy in the treatment of solid tumors and in hematology-oncology. Advances and disappointments].

作者信息

Jochims C, Mazitschek U, Jäger D, Goldschmidt H

机构信息

Nationales Centrum für Tumorerkrankungen, Heidelberg, Germany.

出版信息

Internist (Berl). 2006 Jun;47(6):633-41. doi: 10.1007/s00108-006-1626-7.

DOI:10.1007/s00108-006-1626-7
PMID:16767478
Abstract

The development and clinical introduction of targeted therapies has resulted in significant progress for the treatment of malignant diseases. These forms of therapy supplement traditional methods of chemotherapy, radiation, and surgery. As new therapies increase the complexity of therapeutic options in oncology, the treatment costs steadily climb as well. Parameters need to be identified which will predict a response to new substances, and this effort is the subject of ongoing studies.

摘要

靶向治疗的发展及临床应用已在恶性疾病治疗方面取得显著进展。这些治疗方式补充了传统的化疗、放疗及手术方法。随着新疗法增加了肿瘤学治疗选择的复杂性,治疗成本也在稳步攀升。需要确定能够预测对新物质反应的参数,而这正是正在进行的研究课题。

相似文献

1
[Targeted therapy in the treatment of solid tumors and in hematology-oncology. Advances and disappointments].[实体瘤及血液肿瘤学治疗中的靶向治疗。进展与失望]
Internist (Berl). 2006 Jun;47(6):633-41. doi: 10.1007/s00108-006-1626-7.
2
[Major therapeutic advances and new perspectives in onco-hematology].[肿瘤血液学的重大治疗进展与新展望]
Bull Cancer. 2013 Jun;100(6):587-99. doi: 10.1684/bdc.2013.1751.
3
Targeted and tailored therapy in hemato-oncology: vision for the 21st century.血液肿瘤学中的靶向与个体化治疗:21世纪展望
Isr Med Assoc J. 2006 Dec;8(12):843-4.
4
The promise of targeted therapy: cancer drugs become more specific.
Cleve Clin J Med. 2004 Jul;71(7):551-60. doi: 10.3949/ccjm.71.7.551.
5
Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy.癌症的先进靶向疗法:药物纳米载体,化疗的未来。
Eur J Pharm Biopharm. 2015 Jun;93:52-79. doi: 10.1016/j.ejpb.2015.03.018. Epub 2015 Mar 23.
6
[Advances in medical oncology].[医学肿瘤学进展]
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2006 Jun;28(3):305-10.
7
[Hematology 2010].
Dtsch Med Wochenschr. 2010 Jun;135(25-26):1322-5. doi: 10.1055/s-0030-1255163. Epub 2010 Jun 16.
8
Epigenetic targets for the treatment of neurodegenerative diseases.用于治疗神经退行性疾病的表观遗传靶点。
Clin Pharmacol Ther. 2016 May;99(5):481. doi: 10.1002/cpt.323. Epub 2016 Jan 12.
9
[Hematology 2008].
Dtsch Med Wochenschr. 2008 Jun;133(25-26):1400-4. doi: 10.1055/s-2008-1081088.
10
[Targeted and gene therapy for hematology and oncology diseases in children].儿童血液学和肿瘤学疾病的靶向治疗与基因治疗
Zhonghua Er Ke Za Zhi. 2024 Oct 2;62(10):905-908. doi: 10.3760/cma.j.cn112140-20240802-00549.

本文引用的文献

1
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group.厄洛替尼联合吉西他滨与吉西他滨单药治疗晚期胰腺癌患者的比较:加拿大国家癌症研究所临床试验组的一项III期试验
J Clin Oncol. 2007 May 20;25(15):1960-6. doi: 10.1200/JCO.2006.07.9525. Epub 2007 Apr 23.
2
Concurrent cetuximab, cisplatin, and concomitant boost radiotherapy for locoregionally advanced, squamous cell head and neck cancer: a pilot phase II study of a new combined-modality paradigm.西妥昔单抗、顺铂与同期增量放疗联合治疗局部晚期头颈部鳞状细胞癌:一种新型联合治疗模式的II期初步研究
J Clin Oncol. 2006 Mar 1;24(7):1072-8. doi: 10.1200/JCO.2004.00.1792.
3
Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck.放疗联合西妥昔单抗治疗头颈部鳞状细胞癌。
N Engl J Med. 2006 Feb 9;354(6):567-78. doi: 10.1056/NEJMoa053422.
4
A systematic review of phase-II trials of thalidomide monotherapy in patients with relapsed or refractory multiple myeloma.沙利度胺单药治疗复发或难治性多发性骨髓瘤患者的II期试验的系统评价。
Br J Haematol. 2006 Mar;132(5):584-93. doi: 10.1111/j.1365-2141.2005.05914.x.
5
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer.HER2阳性乳腺癌辅助化疗后使用曲妥珠单抗。
N Engl J Med. 2005 Oct 20;353(16):1659-72. doi: 10.1056/NEJMoa052306.
6
Treatment of metastatic renal cell carcinoma with a combination of bevacizumab and erlotinib.贝伐单抗和厄洛替尼联合治疗转移性肾细胞癌。
J Clin Oncol. 2005 Nov 1;23(31):7889-96. doi: 10.1200/JCO.2005.01.8234. Epub 2005 Oct 3.
7
Outcome of patients with advanced gastro-intestinal stromal tumours crossing over to a daily imatinib dose of 800 mg after progression on 400 mg.晚期胃肠道间质瘤患者在400mg伊马替尼治疗进展后改用每日800mg剂量的治疗结果。
Eur J Cancer. 2005 Aug;41(12):1751-7. doi: 10.1016/j.ejca.2005.04.034.
8
Erlotinib in lung cancer - molecular and clinical predictors of outcome.厄洛替尼用于肺癌治疗——疗效的分子及临床预测指标
N Engl J Med. 2005 Jul 14;353(2):133-44. doi: 10.1056/NEJMoa050736.
9
Erlotinib in previously treated non-small-cell lung cancer.厄洛替尼用于既往接受过治疗的非小细胞肺癌。
N Engl J Med. 2005 Jul 14;353(2):123-32. doi: 10.1056/NEJMoa050753.
10
[Basics of molecular diagnostics and therapy of malignant tumors].[恶性肿瘤的分子诊断与治疗基础]
Internist (Berl). 2005 Aug;46(8):835-6, 838-42, 844-6. doi: 10.1007/s00108-005-1470-1.