降钙素原和白细胞介素-6值对预测癌症发热性中性粒细胞减少儿童菌血症和临床脓毒症的诊断准确性。 - Suppr

Diagnostic accuracy of procalcitonin and interleukin-6 values for predicting bacteremia and clinical sepsis in febrile neutropenic children with cancer.

作者信息

Kitanovski L, Jazbec J, Hojker S, Gubina M, Derganc M

机构信息

Department of Pediatrics, Division of Oncology and Hematology, University Medical Centre Ljubljana, Vrazov trg 1, 1000, Ljubljana, Slovenia.

出版信息

Eur J Clin Microbiol Infect Dis. 2006 Jun;25(6):413-5. doi: 10.1007/s10096-006-0143-x.

DOI:10.1007/s10096-006-0143-x

PMID:16767494

Abstract

摘要

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Diagnostic accuracy of procalcitonin and interleukin-6 values for predicting bacteremia and clinical sepsis in febrile neutropenic children with cancer.降钙素原和白细胞介素-6值对预测癌症发热性中性粒细胞减少儿童菌血症和临床脓毒症的诊断准确性。

Eur J Clin Microbiol Infect Dis. 2006 Jun;25(6):413-5. doi: 10.1007/s10096-006-0143-x.

The predictive value of soluble biomarkers (CD14 subtype, interleukin-2 receptor, human leucocyte antigen-G) and procalcitonin in the detection of bacteremia and sepsis in pediatric oncology patients with chemotherapy-induced febrile neutropenia.可溶性生物标志物（CD14 亚型、白细胞介素-2 受体、人类白细胞抗原-G）和降钙素原在化疗引起的发热性中性粒细胞减少症的儿科肿瘤患者中性粒细胞减少伴发热中检测菌血症和脓毒症的预测价值。

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Elevated procalcitonin predicts Gram-negative sepsis in haematological patients with febrile neutropenia.降钙素原升高可预测血液系统发热性中性粒细胞减少患者的革兰阴性菌败血症。

Scand J Infect Dis. 2011 Jul;43(6-7):471-8. doi: 10.3109/00365548.2011.554855. Epub 2011 Feb 7.

Procalcitonin to detect invasive bacterial infection in non-toxic-appearing infants with fever without apparent source in the emergency department.降钙素原在急诊科表现无中毒症状且发热但无明显病因的婴儿中用于检测侵袭性细菌感染。

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Markers of bacteremia in febrile neutropenic patients with hematological malignancies: procalcitonin and IL-6 are more reliable than C-reactive protein.血液系统恶性肿瘤发热性中性粒细胞减少患者菌血症的标志物：降钙素原和白细胞介素-6比C反应蛋白更可靠。

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Procalcitonin-a sensitive inflammation marker of febrile episodes in neutropenic children with cancer.降钙素原——癌症中性粒细胞减少发热患儿发热发作的敏感炎症标志物。

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Procalcitonin in paediatric cancer patients: its diagnostic relevance is superior to that of C-reactive protein, interleukin 6, interleukin 8, soluble interleukin 2 receptor and soluble tumour necrosis factor receptor II.降钙素原在儿科癌症患者中的作用：其诊断相关性优于C反应蛋白、白细胞介素6、白细胞介素8、可溶性白细胞介素2受体和可溶性肿瘤坏死因子受体II。

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Interleukin-6, interleukin-8, and a rapid and sensitive assay for calcitonin precursors for the determination of bacterial sepsis in febrile neutropenic children.白细胞介素-6、白细胞介素-8以及一种用于测定发热性中性粒细胞减少儿童细菌性败血症的降钙素前体的快速灵敏检测方法。

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Predictors of severe sepsis not clinically apparent during the first twenty-four hours of hospitalization in children with cancer, neutropenia, and fever: a prospective, multicenter trial.癌症、中性粒细胞减少症和发热患儿住院首24小时内无临床明显表现的严重脓毒症预测因素：一项前瞻性多中心试验

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Predictive value of PCT and IL-6 for bacterial infection in children with cancer and febrile neutropenia.降钙素原和白细胞介素-6 对癌症合并发热性中性粒细胞减少症患儿细菌感染的预测价值。

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本文引用的文献

Pediatr Crit Care Med. 2005 Mar;6(2):129-35. doi: 10.1097/01.PCC.0000149317.15274.48.

Use of inflammatory markers for early detection of bacteraemia in patients with febrile neutropenia.使用炎症标志物早期检测发热性中性粒细胞减少症患者的菌血症

Scand J Infect Dis. 2004;36(5):365-71. doi: 10.1080/00365540410020217.

Eur J Clin Microbiol Infect Dis. 2004 Jul;23(7):539-44. doi: 10.1007/s10096-004-1156-y. Epub 2004 Jun 22.

Potential use of procalcitonin as a diagnostic criterion in febrile neutropenia: experience from a multicentre study.降钙素原作为发热性中性粒细胞减少症诊断标准的潜在应用：一项多中心研究的经验

Clin Microbiol Infect. 2004 Jul;10(7):628-33. doi: 10.1111/j.1469-0691.2004.00883.x.

Assessment of procalcitonin as a diagnostic and prognostic marker in patients with solid tumors and febrile neutropenia.评估降钙素原作为实体瘤合并发热性中性粒细胞减少症患者的诊断和预后标志物。

Cancer. 2004 Jun 1;100(11):2462-9. doi: 10.1002/cncr.20275.

Procalcitonin levels in plasma in oncohaematologic patients with and without bacterial infections.患有和未患有细菌感染的肿瘤血液学患者血浆中的降钙素原水平。

Clin Chim Acta. 2004 Feb;340(1-2):149-52. doi: 10.1016/j.cccn.2003.10.014.

Br J Haematol. 2000 Dec;111(4):1093-102. doi: 10.1046/j.1365-2141.2000.02458.x.

Procalcitonin: a diagnostic marker of bacterial infection in neutropenic cancer patients with fever?降钙素原：发热的中性粒细胞减少癌症患者细菌感染的诊断标志物？

Infection. 2000 Nov-Dec;28(6):398-400. doi: 10.1007/s150100070014.

An analysis of interleukin-8, interleukin-6 and C-reactive protein serum concentrations to predict fever, gram-negative bacteremia and complicated infection in neutropenic cancer patients.分析白细胞介素-8、白细胞介素-6和C反应蛋白血清浓度以预测中性粒细胞减少的癌症患者发热、革兰氏阴性菌血症和复杂感染。

Infection. 1998 Jul-Aug;26(4):213-21. doi: 10.1007/BF02962366.

C-reactive protein: a valuable aid for the management of febrile children with cancer and neutropenia.C反应蛋白：对患有癌症和中性粒细胞减少症的发热儿童进行管理的一项重要辅助指标

Clin Infect Dis. 1994 Apr;18(4):589-95. doi: 10.1093/clinids/18.4.589.

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Diagnostic accuracy of procalcitonin and interleukin-6 values for predicting bacteremia and clinical sepsis in febrile neutropenic children with cancer.

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