Lips P
VU Medisch Centrum, afd Inwendige Geneeskunde, Amsterdam.
Ned Tijdschr Geneeskd. 2006 May 27;150(21):1180.
Vitamin-D deficiency is common in immobile elderly and non-Western immigrants and has been related to muscle weakness in these populations. When serum calcidiol concentrations are below 50 nmol/l, parathyroid hormone concentrations increase, causing bone resorption. Bone mineral density and proximal muscle strength increase as the serum concentration ofcalcidiol increases. Vitamin-D supplementation is reported to reduce the incidence of fractures in nursing home residents. Dutch guidelines recommend vitamin-D supplementation for nursing home residents and for those who are house-bound. Fortification of milk and other foods with vitamin D in the United States and Sweden has led to a better nutritional state with respect to vitamin D than in the Netherlands. Therefore the dairy industry should be allowed to add vitamin D to dairy products to prevent fractures.
维生素D缺乏在行动不便的老年人和非西方移民中很常见，并且与这些人群的肌肉无力有关。当血清骨化二醇浓度低于50 nmol/l时，甲状旁腺激素浓度会升高，导致骨质吸收。随着血清骨化二醇浓度的升高，骨矿物质密度和近端肌肉力量也会增加。据报道，补充维生素D可降低疗养院居民骨折的发生率。荷兰指南建议为疗养院居民和居家者补充维生素D。在美国和瑞典，在牛奶和其他食物中添加维生素D强化剂，使得维生素D的营养状况比荷兰更好。因此，应该允许乳制品行业在乳制品中添加维生素D以预防骨折。
