Miranda Rubén, Blanco Eduardo, Begega Azucena, Rubio Sandra, Arias Jorge L
Laboratory of Psychobiology, School of Psychology, University of Oviedo, Oviedo, Spain.
Behav Neurosci. 2006 Jun;120(3):641-50. doi: 10.1037/0735-7044.120.3.641.
Hippocampal and striatal systems are widely related to spatial tasks. Depending on the strategies used, different memory systems can be activated. In this study, the authors used the cytochrome c-oxidase technique as a functional marker of the hippocampal and dorsal striatum activity related to training in several water maze tasks. Current results show a differential participation of the hippocampal and striatal systems in navigation. When spatial information is relevant, participation of the hippocampal system is more important, and when the task is similar to a response learning one, the striatal system is more active. According to computational models, CA3 seems to be more active when the associative demand is higher, whereas CA1 and dentate gyrus activity are higher when spatial information processing is required.
海马体和纹状体系统与空间任务广泛相关。根据所使用的策略，不同的记忆系统会被激活。在本研究中，作者使用细胞色素c氧化酶技术作为与几种水迷宫任务训练相关的海马体和背侧纹状体活动的功能标记。当前结果显示海马体和纹状体系统在导航中发挥不同作用。当空间信息相关时，海马体系统的参与更为重要；而当任务类似于反应学习任务时，纹状体系统更为活跃。根据计算模型，当联想需求较高时，CA3似乎更为活跃；而当需要处理空间信息时，CA1和齿状回的活动则更为活跃。
