Werner U, Schmidt J, Szelenyi I
Department of Pharmacology, ASTA Pharma AG, Frankfurt/Main, FRG.
Agents Actions Suppl. 1991;32:243-7. doi: 10.1007/978-3-0348-7405-2_33.
The effects of the novel antiasthmatic/antiallergic compound azelastine on IL-1 beta were investigated in vitro and in vivo. In leukocytes both, intra- and extracellular IL-1 generation stimulated by LPS was inhibited dose dependently. In contrast azelastine did not prevent IL-1 beta-induced immigration of PMNs into the mouse ear. These findings suggest that azelastine is not an IL-1 antagonist but inhibits IL-1 synthesis and/or release in leukocytes.
研究了新型抗哮喘/抗过敏化合物氮卓斯汀对白细胞介素-1β（IL-1β）的体内外作用。在白细胞中，脂多糖（LPS）刺激产生的细胞内和细胞外IL-1均受到剂量依赖性抑制。相比之下，氮卓斯汀并不能阻止IL-1β诱导的中性粒细胞向小鼠耳部迁移。这些发现表明，氮卓斯汀不是一种IL-1拮抗剂，而是在白细胞中抑制IL-1的合成和/或释放。
