Werner U, Schmidt J, Szelenyi I
Department of Pharmacology, ASTA Medica AG, Frankfurt, Germany.
Agents Actions. 1994 Mar;41(1-2):99-100. doi: 10.1007/BF01986405.
The effects of the novel antiasthmatic/antiallergic compound flezelastine on LPS-induced actions were investigated in vitro and in vivo. In monocytes, IL-1 beta generation stimulated by LPS was inhibited dose dependently. In vivo, LPS-induced fever in rats, which is at least partly driven by the release of IL-1 beta, was also inhibited by flezelastine. These findings suggest that flezelastine inhibits IL-1 synthesis and/or release in vitro and in vivo.
在体外和体内研究了新型抗哮喘/抗过敏化合物非索非那定对脂多糖（LPS）诱导作用的影响。在单核细胞中，LPS刺激产生的白细胞介素-1β（IL-1β）呈剂量依赖性受到抑制。在体内，LPS诱导的大鼠发热（至少部分由IL-1β释放驱动）也被非索非那定抑制。这些发现表明，非索非那定在体外和体内均抑制IL-1的合成和/或释放。
