Wang Chengyin, Shao Xiaoqiu, Liu Qingxiu, Qu Qishu, Yang Gongjun, Hu Xiaoya
Department of Chemistry and Chemical Engineering, Yongzhou 225002, PR China.
J Pharm Biomed Anal. 2006 Sep 18;42(2):237-44. doi: 10.1016/j.jpba.2006.03.038.
Carbon nanotubes (CNTs) and cysteic acid based on electrochemical oxidation of L-cysteine (CySH) to form a novel composite thin film material at a glassy carbon electrode (GCE) for electroanalytical determination of nimesulide. The determination of nimesulide at the composite modified electrode with strong accumulation of nimesulide was studied by differential pulse voltammetry (DPV). The peak current obtained at +1.251 V (versus SCE) from DPV was linearly dependent on the nimesulide concentration in the range of 1.0 x 10(-7) -1.0 x 10(-5) M in 0.05 M H(2)SO(4) solution with a correlation coefficient of 0.997. The detection limit (S/N = 3) was found to be 5.0 x 10(-8) M. The low-cost modified electrode showed good sensitivity, selectivity, stability and had been applied to the determination of nimesulide in pharmaceutical formulation and human serum samples with satisfactory results.
碳纳米管（CNTs）与基于L-半胱氨酸（CySH）电化学氧化形成的半胱氨酸在玻碳电极（GCE）上制备了一种新型复合薄膜材料，用于尼美舒利的电分析测定。采用差分脉冲伏安法（DPV）研究了在复合修饰电极上对尼美舒利进行强富集时尼美舒利的测定。在0.05 M H₂SO₄溶液中，通过DPV在+1.251 V（相对于SCE）处获得的峰电流与尼美舒利浓度在1.0×10⁻⁷ - 1.0×10⁻⁵ M范围内呈线性关系，相关系数为0.997。检测限（S/N = 3）为5.0×10⁻⁸ M。这种低成本的修饰电极具有良好的灵敏度、选择性和稳定性，并已应用于药物制剂和人血清样品中尼美舒利的测定，结果令人满意。
