Department of Applied Chemistry, Cochin University of Science and Technology, Kochi, India.
J Fluoresc. 2013 May;23(3):473-8. doi: 10.1007/s10895-013-1170-5. Epub 2013 Feb 9.
Fluorescent PET (Photoinduced Electron Transfer) has been of particular growth in recent times. A novel PET based fluorescent sensor using unmodified CdSe quantum dots (QDs) has been developed for the trace determination of Nimesulide (NIM). The sensor is based on the selective fluorescence quenching of quantum dots by NIM in presence of other NSAIDs and is found that intensity of quenching is linearly related to NIM concentration in the range 8.2 × 10(-7) - 4.01 × 10(-5) M. The mechanism of interaction is discussed. Finally, the potential application of the proposed method for the trace determination of NIM in pharmaceutical formulation is demonstrated.
荧光 PET（光诱导电子转移）在最近得到了特别的发展。一种新型的基于荧光的 PET 传感器，使用未经修饰的 CdSe 量子点（QDs），已经被开发出来，用于痕量测定尼美舒利（NIM）。该传感器基于在其他 NSAIDs 存在的情况下，通过 NIM 选择性地猝灭量子点的荧光，并且发现猝灭强度与 NIM 浓度在 8.2×10(-7) - 4.01×10(-5) M 范围内呈线性关系。讨论了相互作用的机制。最后，展示了该方法在药物制剂中痕量测定 NIM 的潜在应用。
