Körbling M, Fliedner T M, Holle R, Magrin S, Baumann M, Holdermann E, Eberhardt K
Department of Internal Medicine V, Heidelberg University, Germany.
Bone Marrow Transplant. 1991 May;7(5):343-9.
Complete and sustained hemopoietic function following myeloablative therapy can be successfully achieved by autologous transfusion of blood derived hemopoietic stem cells. It was the purpose of this study to compare autologous blood stem cell transplantation (ABSCT) in 20 patients with autologous transplantation of a mafosfamide purged marrow (pABMT) in 23 patients; all were transplanted in first complete remission (CR) of acute myelogenous leukemia (AML) using the same pretransplant regimen (14.4 Gy total body irradiation and 200 mg/kg cyclophosphamide). The autografts, mostly differing in source of hemopoietic stem cells, cell composition and CFU-GM number, were evaluated for their ability to reconstitute hemopoiesis and induce long-term disease-free survival (DFS). Prior to harvest, hemopoietic stem cells were mobilized by inducing transient myelosuppression (ara-C 100 mg/m2 every 12 h s.c. days 1-5 and daunorubicin 45 mg/m2, days 3 and 4) followed by an overshooting of peripheral stem cell concentration.(ABSTRACT TRUNCATED AT 250 WORDS)
通过自体输注血液来源的造血干细胞，可成功实现清髓治疗后完整且持续的造血功能。本研究旨在比较20例患者的自体血干细胞移植（ABSCT）与23例患者的马磷酰胺净化骨髓自体移植（pABMT）；所有患者均在急性髓系白血病（AML）的首次完全缓解期（CR）接受移植，采用相同的移植前方案（全身照射14.4 Gy和环磷酰胺200 mg/kg）。这些自体移植物在造血干细胞来源、细胞组成和CFU-GM数量上大多不同，对其重建造血和诱导长期无病生存（DFS）的能力进行了评估。在采集前，通过诱导短暂的骨髓抑制（阿糖胞苷100 mg/m²，每12小时皮下注射，第1 - 5天；柔红霉素45 mg/m²，第3天和第4天）来动员造血干细胞，随后外周干细胞浓度会出现峰值。（摘要截断于250字）
