维生素D受体基因BsmI和TaqI多态性与骨折风险：一项荟萃分析。
Vitamin D receptor gene BsmI and TaqI polymorphisms and fracture risk: a meta-analysis.
作者信息
Fang Yue, Rivadeneira Fernando, van Meurs Joyce B J, Pols Huib A P, Ioannidis John P A, Uitterlinden André G
机构信息
Department of Internal Medicine, Erasmus MC, 3015 GD Rotterdam, The Netherlands.
出版信息
Bone. 2006 Oct;39(4):938-45. doi: 10.1016/j.bone.2006.04.016.
INTRODUCTION
Fracture is the major clinical outcome of osteoporosis. The vitamin D receptor (VDR) gene is thought to be a candidate gene for osteoporosis. Many genetic studies have suggested an association of VDR polymorphisms and osteoporosis, but evidence remains conflicting.
MATERIALS AND METHODS
We searched published studies from 1996 to September 2005 through PubMed and evaluated the genetic effect of the BsmI and TaqI polymorphism of VDR on fracture risk in a meta-analysis. Thirteen studies with a total of 20 eligible comparisons (1632 fracture cases and 5203 controls) were analyzed with fixed and random effects models.
RESULT
No evidence of relationship between the VDR BsmI or TaqI polymorphism and fracture risk was observed with any genetic model. The odds ratio (95% confidence interval) of b-allele versus B-allele was 0.98 (0.86-1.12) with random effects calculations. There was significant between-study heterogeneity. Small studies did not differ significantly from larger ones.
CONCLUSION
No relationship of the VDR BsmI or TaqI polymorphism and fracture risk was found in the meta-analysis of published data.
引言
骨折是骨质疏松症的主要临床后果。维生素D受体（VDR）基因被认为是骨质疏松症的候选基因。许多遗传学研究表明VDR基因多态性与骨质疏松症之间存在关联，但证据仍存在矛盾。
材料与方法
我们通过PubMed搜索了1996年至2005年9月发表的研究，并在一项荟萃分析中评估了VDR的BsmI和TaqI多态性对骨折风险的遗传效应。使用固定效应模型和随机效应模型分析了13项研究，共20项符合条件的比较（1632例骨折病例和5203例对照）。
结果
在任何遗传模型中，均未观察到VDR BsmI或TaqI多态性与骨折风险之间存在关联的证据。采用随机效应计算，b等位基因与B等位基因的比值比（95%置信区间）为0.98（0.86 - 1.12）。研究间存在显著的异质性。小型研究与大型研究之间无显著差异。
结论
在对已发表数据的荟萃分析中，未发现VDR BsmI或TaqI多态性与骨折风险之间存在关联。
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