Harwerth Ronald S, Quigley Harry A
College of Optometry, University of Houston, Tex 77204-2020, USA.
Arch Ophthalmol. 2006 Jun;124(6):853-9. doi: 10.1001/archopht.124.6.853.
To determine whether the structure-function relationships for glaucoma in humans and experimental glaucoma in monkeys are similar.
The study was based on retinal ganglion cell density and visual thresholds in patients with documented glaucoma. Data were analyzed with a model that predicted ganglion cell density from standard clinical perimetry, which was then compared with histologic cell counts.
The model, without free parameters, produced accurate and relatively precise quantification of ganglion cell density associated with visual field defects. For 437 sets of data, the unity correlation for predicted vs measured cell density had a coefficient of determination of 0.39. The mean absolute deviation of the predicted vs measured values was 2.59 decibels (dB), and the mean +/- SD of the distribution of residual errors of prediction was -0.26 +/- 3.22 dB.
Visual field defects based on standard clinical perimetry are proportional to neural losses caused by glaucoma.
The evidence for quantitative structure-function relationships provides a scientific basis for interpreting glaucomatous neuropathy from visual thresholds and supports the application of standard perimetry to establish the stage of the disease.
确定人类青光眼与猴实验性青光眼的结构-功能关系是否相似。
该研究基于已确诊青光眼患者的视网膜神经节细胞密度和视觉阈值。数据采用一种根据标准临床视野检查预测神经节细胞密度的模型进行分析，然后与组织学细胞计数进行比较。
该无自由参数的模型对与视野缺损相关的神经节细胞密度进行了准确且相对精确的量化。对于437组数据，预测的细胞密度与测量的细胞密度的一致性相关性的决定系数为0.39。预测值与测量值的平均绝对偏差为2.59分贝（dB），预测残余误差分布的均值±标准差为-0.26±3.22 dB。
基于标准临床视野检查的视野缺损与青光眼所致神经损伤成正比。
定量结构-功能关系的证据为从视觉阈值解释青光眼性神经病变提供了科学依据，并支持应用标准视野检查来确定疾病阶段。
