Onuigbo W I
Arch Pathol. 1975 Jun;99(6):342-3.
The relationship between tumor "seed" and tissue "soil" in blood-borne metastasis is poorly understood. Therefore, an explanatory human model is proposed. It is based on the hypothesis that the spread of lung cancer cells to the adrenal vein provides in man not only a variable attribute, lung cancer seed, but also a constant attribute, adrenal venous soil, as in a scientific experiment. Out of 100 cases of lung cancer, four histologic types proved their invasive potentiality in 45 subjects by colonizing the adrenal parenchyma proper and yet differed appreciably in their ability to grow in the adrenal venous blood. Hence, in all probability, the systematic study of venous blood will help in the discovery of the potentialities and limitations of human blood in tumor metastasis.
血行转移中肿瘤“种子”与组织“土壤”之间的关系尚不清楚。因此，提出了一个解释性的人体模型。它基于这样一种假设，即肺癌细胞向肾上腺静脉的扩散在人体中不仅提供了一个可变属性——肺癌种子，还提供了一个恒定属性——肾上腺静脉土壤，就像在科学实验中一样。在100例肺癌病例中，四种组织学类型通过在肾上腺实质内定植，在45名受试者中证明了它们的侵袭潜力，但它们在肾上腺静脉血中的生长能力有明显差异。因此，很有可能，对静脉血的系统研究将有助于发现人体血液在肿瘤转移中的潜力和局限性。
