Choi H, Winawer M R, Kalachikov S, Pedley T A, Hauser W A, Ottman R
Department of Neurology, Columbia University, New York, NY 10032, USA.
Neurology. 2006 Jun 13;66(11):1648-53. doi: 10.1212/01.wnl.0000218302.03570.85.
To develop standardized definitions for classification of partial seizure symptoms for use in genetic research on the epilepsies, and evaluate inter-rater reliability of classifications based on these definitions.
The authors developed the Partial Seizure Symptom Definitions (PSSD), which include standardized definitions of 41 partial seizure symptoms within the sensory, autonomic, aphasic, psychic, and motor categories. Based on these definitions, two epileptologists independently classified partial seizures in 75 individuals from 34 families selected because one person had ictal auditory symptoms or aphasia. The data used for classification consisted of standardized diagnostic interviews with subjects and family informants, and medical records obtained from treating neurologists. Agreement was assessed by kappa.
Agreement between the two neurologists using the PSSD was "substantial" or "almost perfect" for most symptom categories.
Use of standardized definitions for classification of partial seizure symptoms such as those in the Partial Seizure Symptom Definitions should improve reliability and accuracy in future genetic studies of the epilepsies.
制定用于癫痫遗传研究的部分性发作症状分类的标准化定义，并评估基于这些定义的分类的评分者间信度。
作者制定了部分性发作症状定义（PSSD），其中包括感觉、自主神经、失语、精神和运动类别内41种部分性发作症状的标准化定义。基于这些定义，两名癫痫专家对来自34个家庭的75名个体的部分性发作进行了独立分类，这些家庭是因为有一人有发作期听觉症状或失语而被选中的。用于分类的数据包括对受试者和家庭 informant 的标准化诊断访谈，以及从治疗神经科医生处获得的医疗记录。通过kappa评估一致性。
对于大多数症状类别，两名神经科医生使用PSSD的一致性为“高度”或“几乎完美”。
使用标准化定义对部分性发作症状进行分类，如部分性发作症状定义中的那些，应能提高未来癫痫遗传研究的信度和准确性。
