特发性震颤的神经病理学发现。
Neuropathologic findings in essential tremor.
作者信息
Louis E D, Vonsattel J P G, Honig L S, Ross G W, Lyons K E, Pahwa R
机构信息
GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
出版信息
Neurology. 2006 Jun 13;66(11):1756-9. doi: 10.1212/01.wnl.0000218162.80315.b9.
Pathologic findings, including cerebellar changes and brainstem Lewy bodies, distinguished 10 essential tremor (ET) cases from 12 controls. Numbers of torpedoes (p = 0.009) and Bergmann glia (p = 0.046) were increased in cases. Six cases (60%) had Lewy bodies vs 2 controls (16.7%) (odds ratio 7.5, 95% CI 1.04 to 54.1; p = 0.035). Four of these six had an atypical distribution of brainstem Lewy bodies. ET may be pathologically heterogeneous.
病理检查结果，包括小脑改变和脑干路易小体，将10例特发性震颤（ET）病例与12例对照区分开来。病例组中鱼雷样小体数量（p = 0.009）和伯格曼胶质细胞数量（p = 0.046）增加。6例（60%）有路易小体，而对照组有2例（16.7%）（比值比7.5，95%可信区间1.04至54.1；p = 0.035）。这6例中有4例脑干路易小体分布不典型。ET在病理上可能具有异质性。
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