Clyman Ronald I
School of Medicine, Cardiovascular Research Institute, University of California, San Francisco, Calif., USA.
Biol Neonate. 2006;89(4):330-5. doi: 10.1159/000092870. Epub 2006 Jun 1.
A patent ductus arteriosus (PDA) results in increased pulmonary blood flow and redistribution of flow to other organs. Several co-morbidities (i.e., necrotizing enterocolitis, intracranial hemorrhage, pulmonary edema/hemorrhage, bronchopulmonary dysplasia, and retinopathy) are associated with the presence of a PDA, but whether or not a PDA is responsible for their development is still unclear. In this review, comparative physiology between the full term and preterm newborn and the barriers preventing the necessary cascade of events leading to permanent constriction of the PDA are reviewed.
动脉导管未闭（PDA）会导致肺血流量增加以及血流重新分布至其他器官。几种合并症（即坏死性小肠结肠炎、颅内出血、肺水肿/出血、支气管肺发育不良和视网膜病变）与PDA的存在相关，但PDA是否是这些合并症发生的原因仍不明确。在本综述中，将对足月儿和早产儿之间的比较生理学以及阻碍导致PDA永久性闭合的必要事件级联反应的障碍进行综述。
