Xing Yi, Lee Christopher
Molecular Biology Institute, Center for Genomics and Proteomics, Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.
Nat Rev Genet. 2006 Jul;7(7):499-509. doi: 10.1038/nrg1896. Epub 2006 Jun 13.
Genome-wide analyses of alternative splicing have established its nearly ubiquitous role in gene regulation in many organisms. Genome sequencing and comparative genomics have made it possible to look in detail at the evolutionary history of specific alternative exons or splice sites, resulting in a flurry of publications in recent years. Here, we consider how alternative splicing has contributed to the evolution of modern genomes, and discuss constraints on evolution associated with alternative splicing that might have important medical implications.
对可变剪接的全基因组分析已证实其在许多生物体的基因调控中几乎无处不在。基因组测序和比较基因组学使详细研究特定可变外显子或剪接位点的进化历史成为可能，这导致近年来涌现出大量相关出版物。在此，我们探讨可变剪接如何促进现代基因组的进化，并讨论与可变剪接相关的进化限制，这些限制可能具有重要的医学意义。
