Bhasi Ashwini, Pandey Ram Vinay, Utharasamy Suriya Prabha, Senapathy Periannan
Department of Human Genetics, Genome Technologies, Inc., 8000 Excelsior Drive, Madison, WI 53717, USA.
Bioinformatics. 2007 Jul 15;23(14):1815-23. doi: 10.1093/bioinformatics/btm084. Epub 2007 Mar 7.
Despite increased availability of genome annotation data, a comprehensive resource for in-depth analysis of splice signal distributions and alternative splicing (AS) patterns in eukaryote genomes is still lacking. To meet this need, we have developed EuSplice--a unique splice-centric database which provides reliable splice signal and AS information for 23 eukaryotes.
The EuSplice database contains 95,822 AS events and 2.1 million splice signals associated with over 270,000 protein-coding genes. The intuitive, user-friendly EuSplice web interface has powerful data mining and graphics capabilities for inter-genomic comparative analysis of splice signals, putative cryptic splice sites and AS events. Moreover, the seamless integration of splicing data to extensive gene-specific annotations, such as homolog annotations, functional information, mutations and sequence details makes EuSplice a powerful one-stop information resource for investigating the molecular mechanisms of complex splicing events, disease associations and the evolution of splicing in eukaryotes.
http://66.170.16.154/EuSplice.
Supplementary tables and figures at Bioinfo online.
尽管基因组注释数据的可用性有所提高，但仍缺乏一个用于深入分析真核生物基因组中剪接信号分布和可变剪接（AS）模式的综合资源。为满足这一需求，我们开发了EuSplice——一个独特的以剪接为中心的数据库，它为23种真核生物提供了可靠的剪接信号和AS信息。
EuSplice数据库包含95,822个AS事件以及与超过270,000个蛋白质编码基因相关的210万个剪接信号。直观、用户友好的EuSplice网络界面具有强大的数据挖掘和图形功能，可用于剪接信号、潜在隐蔽剪接位点和AS事件的基因组间比较分析。此外，剪接数据与广泛的基因特异性注释（如同源物注释、功能信息、突变和序列细节）的无缝整合，使EuSplice成为一个强大的一站式信息资源，用于研究复杂剪接事件的分子机制、疾病关联以及真核生物中剪接的进化。
http://66.170.16.154/EuSplice。
Bioinfo在线的补充表格和图。
