Schöder Heiko, Glass Edwin C, Pecking Alain P, Harness Jay K, Wallace Anne M, Hirnle Peter, Alberini Jean L, Vilain Didier, Larson Steven M, Hoh Carl K, Vera David R
Department of Radiology/Nuclear Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Cancer Metastasis Rev. 2006 Jun;25(2):185-201. doi: 10.1007/s10555-006-8498-0.
Progress toward targeting cancer cells is a multi-disciplinary endeavor. In addition to the surgical and oncology specialties, radiologists collaborate with mathematicians, computer scientists, and physicists, in a constant effort to incrementally improve upon the current imaging modalities. Recently, radiologists have formed collaborations with molecular biologists and chemists in order to develop molecular agents that target cancer cells via receptor-substrate or specific physiochemical interactions. In this review, we summarize selected efforts toward molecular targeting of the lymphovascular system. Standard imaging modalities, positron emission tomography, single photon emission tomography, and ultrasound, are reviewed as well as, the targeted introduction of substances for endolymphatic therapy. We also review the current status of sentinel lymph node mapping with radiocolloids and the application of molecular targeting for the development of a radiopharmaceutical specifically designed for sentinel lymph node mapping.
靶向癌细胞的进展是一项多学科的努力。除了外科和肿瘤学专业外，放射科医生还与数学家、计算机科学家和物理学家合作，不断努力逐步改进当前的成像方式。最近，放射科医生与分子生物学家和化学家合作，以开发通过受体 - 底物或特定物理化学相互作用靶向癌细胞的分子试剂。在本综述中，我们总结了在分子靶向淋巴管系统方面的一些努力。回顾了标准成像方式、正电子发射断层扫描、单光子发射断层扫描和超声，以及用于内淋巴治疗的物质的靶向引入。我们还回顾了放射性胶体前哨淋巴结定位的现状以及分子靶向在开发专门用于前哨淋巴结定位的放射性药物中的应用。
