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转移的分子机制。

Molecular mechanisms of metastasis.

作者信息

Hoon Dave S B, Kitago Minoru, Kim Joseph, Mori Takuji, Piris Adriano, Szyfelbein Katherine, Mihm Martin C, Nathanson S David, Padera Timothy P, Chambers Ann F, Vantyghem Sharon A, MacDonald Ian C, Shivers Steven C, Alsarraj Marwan, Reintgen Douglas S, Passlick Bernward, Sienel Wulf, Pantel Klaus

机构信息

Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, CA 90404, USA.

出版信息

Cancer Metastasis Rev. 2006 Jun;25(2):203-20. doi: 10.1007/s10555-006-8500-x.

DOI:10.1007/s10555-006-8500-x
PMID:16770533
Abstract

A major topic covered at the First International Symposium on Cancer Metastasis and the Lymphovascular System was the molecular mechanisms of metastasis. This has become of major interest in recent years as we have discovered new metastasis-related genes and gained understanding of the molecular events of lymphatic metastasis. The symposium covered new aspects and important questions related to the events of metastasis in both humans and animals. The basic and clinical related research covered in this topic represented many disciplines. The presentations showed novel findings and at the same time, raised many new unanswered questions, indicating the limited knowledge we still have regarding the molecular events of metastasis. The hope is that further unraveling of the direct and indirect molecular events of lymphatic metastasis will lead to new approaches in developing effective therapeutics.

摘要

第一届癌症转移与淋巴血管系统国际研讨会涵盖的一个主要主题是转移的分子机制。近年来,这已成为人们主要关注的问题,因为我们发现了新的转移相关基因,并对淋巴转移的分子事件有了更深入的了解。该研讨会涵盖了与人类和动物转移事件相关的新方面和重要问题。本主题涵盖的基础研究和临床相关研究涉及多个学科。这些报告展示了新的发现,同时也提出了许多新的未解决的问题,这表明我们对转移分子事件的了解仍然有限。希望进一步揭示淋巴转移的直接和间接分子事件将为开发有效的治疗方法带来新途径。

相似文献

1
Molecular mechanisms of metastasis.转移的分子机制。
Cancer Metastasis Rev. 2006 Jun;25(2):203-20. doi: 10.1007/s10555-006-8500-x.
2
Tumor-derived lymphangiogenic factors and lymphatic metastasis.肿瘤源性淋巴管生成因子与淋巴转移
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3
Molecular control of lymphatic metastasis.淋巴转移的分子调控
Ann N Y Acad Sci. 2008;1131:225-34. doi: 10.1196/annals.1413.020.
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Lymphatic vessel activation in cancer.癌症中的淋巴管激活
Ann N Y Acad Sci. 2002 Dec;979:120-30. doi: 10.1111/j.1749-6632.2002.tb04873.x.
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Tumor and lymph node lymphangiogenesis--impact on cancer metastasis.肿瘤及淋巴结淋巴管生成——对癌症转移的影响
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Vascular endothelial growth factor-C and C-C chemokine receptor 7 in tumor cell-lymphatic cross-talk promote invasive phenotype.肿瘤细胞与淋巴管相互作用中的血管内皮生长因子-C和C-C趋化因子受体7促进侵袭性表型。
Cancer Res. 2009 Jan 1;69(1):349-57. doi: 10.1158/0008-5472.CAN-08-1875.
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The lymphatic vasculature: recent progress and paradigms.淋巴脉管系统:最新进展与范例
Annu Rev Cell Dev Biol. 2005;21:457-83. doi: 10.1146/annurev.cellbio.21.012704.132338.
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Regional lymph node metastases; a singular manifestation of the process of clinical metastases in cancer: contemporary animal research and clinical reports suggest unifying concepts.区域淋巴结转移:癌症临床转移过程的一种独特表现:当代动物研究和临床报告提出了统一的概念。
Ann Surg Oncol. 2007 Jun;14(6):1790-800. doi: 10.1245/s10434-006-9234-2. Epub 2007 Mar 8.
9
[Current status of research on cancer metastasis].[癌症转移的研究现状]
Gan To Kagaku Ryoho. 1992 Dec;19(14):2289-96.
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Lymphangiogenesis and its relationship with lymphatic metastasis and prognosis in malignant melanoma.淋巴管生成及其在恶性黑色素瘤中与淋巴转移和预后的关系。
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The heterogenic tumor microenvironment of hepatocellular carcinoma and prognostic analysis based on tumor neo-vessels, macrophages and α-SMA.基于肿瘤新生血管、巨噬细胞和α平滑肌肌动蛋白的肝细胞癌异质性肿瘤微环境及预后分析
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A hypoxic signature marks tumors formed by disseminated tumor cells in the BALB-neuT mammary cancer model.在BALB-neuT乳腺癌模型中,缺氧特征标记了由播散肿瘤细胞形成的肿瘤。
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Methylation-associated silencing of MicroRNA-335 contributes tumor cell invasion and migration by interacting with RASA1 in gastric cancer.微小RNA-335的甲基化相关沉默通过与胃癌中的RASA1相互作用促进肿瘤细胞的侵袭和迁移。
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Toward a drug development path that targets metastatic progression in osteosarcoma.走向一条针对骨肉瘤转移进展的药物研发之路。
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