Carrigan D R, Drobyski W R, Russler S K, Tapper M A, Knox K K, Ash R C
Department of Pathology, Medical College of Wisconsin, Milwaukee 53226.
Lancet. 1991 Jul 20;338(8760):147-9. doi: 10.1016/0140-6736(91)90137-e.
Severe interstitial pneumonitis in 2 marrow-transplant recipients was associated with human herpesvirus-6 (HHV-6) infection. The virus was repeatedly detected in respiratory specimens from 1 patient, and HHV-6-infected cells were shown in lung tissue from both patients by immunohistochemical staining. The infected cells were primarily intra-alveolar macrophages, although infected lymphocytes were seen. HHV-6 should be considered as a cause of unexplained lung disease in marrow-transplant recipients and other immunocompromised patients.
