卡塔尔本国居民及居住在卡塔尔的移民中人类疱疹病毒6型（HHV-6）的检测及血清流行率
Human herpes simplex virus-6 (HHV-6) detection and seroprevalence among Qatari nationals and immigrants residing in Qatar.
作者信息
Al-Sadeq Duaa W, Zedan Hadeel T, Aldewik Nader, Elkhider Alaa, Hicazi Asalet, Younes Nadin, Ayoub Houssein H, Raddad Laith Abu, Yassine Hadi M, Nasrallah Gheyath K
机构信息
Biomedical Research Centre, QU Health, Qatar University, Doha, Qatar.
College of Medicine, QU Health, Qatar University, Doha, Qatar.
出版信息
IJID Reg. 2021 Dec 16;2:90-95. doi: 10.1016/j.ijregi.2021.12.005. eCollection 2022 Mar.
BACKGROUND
Human herpes simplex virus-6 (HHV-6) is the causative agent of exanthema subitum. Transmission mainly occurs through salivary secretions, yet blood transfusions and organ transplantations have also been reported as routes of transmission. Studies of seroprevalence of HHV-6 in the Middle East and North Africa (MENA) region and other parts of Asia are scarce. As such, this study aimed to estimate the seroprevalence of HHV-6 among healthy blood donors in Qatar.
METHODS
In total, 620 healthy blood donors from different nationalities residing in Qatar, mainly from the MENA region and Southeast Asia, were tested using a commercial anti-HHV-6 immunoglobulin G (IgG) enzyme-linked immunosorbent assay kit. In addition, HHV-6 DNA from randomly selected samples was tested and quantified using quantitative reverse transcriptase polymerase chain reaction.
RESULTS
Anti-HHV-6 IgG was detected in 71.7% (445/620) [95% confidence interval (CI) 68.2-75.3%] of the tested samples, while 24.3% (61/251) (95% CI 20.0-29.6%) had detectable HHV-6 viraemia. Only 22.5% of individuals with positive IgG status had detectable HHV-6 DNA in their blood, indicating a weak association between viraemia and IgG positivity (P=0.08). Furthermore, no significant difference was associated between HHV-6 viraemia and demographic characteristics, except for nationality.
CONCLUSION
The seroprevalence of HHV-6 in Qatar was found to be similar to rates reported in other parts of the world.
背景
人类疱疹病毒6型（HHV-6）是幼儿急疹的病原体。传播主要通过唾液分泌物发生，但输血和器官移植也被报道为传播途径。关于中东和北非（MENA）地区及亚洲其他地区HHV-6血清流行率的研究很少。因此，本研究旨在估计卡塔尔健康献血者中HHV-6的血清流行率。
方法
总共对620名居住在卡塔尔的不同国籍的健康献血者进行了检测，这些献血者主要来自中东和北非地区及东南亚，使用商用抗HHV-6免疫球蛋白G（IgG）酶联免疫吸附测定试剂盒进行检测。此外，对随机选择的样本中的HHV-6 DNA进行检测，并使用定量逆转录聚合酶链反应进行定量。
结果
在71.7%（445/620）[95%置信区间（CI）68.2-75.3%]的检测样本中检测到抗HHV-6 IgG，而24.3%（61/251）（95% CI 20.0-29.6%）有可检测到的HHV-6病毒血症。在IgG状态为阳性的个体中，只有22.5%的人血液中可检测到HHV-6 DNA，这表明病毒血症与IgG阳性之间的关联较弱（P=0.08）。此外，除国籍外，HHV-6病毒血症与人口统计学特征之间没有显著差异。
结论
发现卡塔尔HHV-6的血清流行率与世界其他地区报道的率相似。
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