Lenzi M, Johnson P J, McFarlane I G, Ballardini G, Smith H M, McFarlane B M, Bridger C, Vergani D, Bianchi F B, Williams R
Istituto di Clinica Medica Generale e Terapia Medica, University of Bologna, Italy.
Lancet. 1991 Aug 3;338(8762):277-80. doi: 10.1016/0140-6736(91)90418-o.
To resolve conflicting reports about the occurrence of antibodies against hepatitis C virus (HCV) in patients with autoimmune chronic active hepatitis (AI-CAH), sera from UK and Italian patients were tested with the original anti-HCV assay (Ortho) and a novel anti-HCV assay (UBI) based entirely on synthetic HCV peptides. 28 (60%) of 47 Italian patients with type-1 AI-CAH were anti-HCV-positive by Ortho ELISA, 25 of whom were also strongly positive by the UBI assay. 15 (60%) of 25 UK patients with type-1 AI-CAH were HCV-positive by Ortho ELISA but only 2 were positive by the UBI assay. Similarly, 29 (88%) of 33 Italian patients with type-2 AI-CAH, but 0 of 10 UK patients, were very strongly anti-HCV-positive with the UBI assay. Italian patients with AI-CAH appear to have a high frequency of genuine exposure to HCV, whereas seropositivity by the Ortho HCV ELISA in UK patients is likely to represent a false-positive result. These findings indicate important geographical and/or genetic influences in autoimmune liver disease among different populations.
为解决关于自身免疫性慢性活动性肝炎（AI-CAH）患者中抗丙型肝炎病毒（HCV）抗体出现情况的相互矛盾的报告，我们使用原始的抗HCV检测方法（Ortho）和一种完全基于合成HCV肽的新型抗HCV检测方法（UBI），对英国和意大利患者的血清进行了检测。47例1型AI-CAH意大利患者中，28例（60%）通过Ortho ELISA检测抗HCV呈阳性，其中25例通过UBI检测也呈强阳性。25例1型AI-CAH英国患者中，15例（60%）通过Ortho ELISA检测HCV呈阳性，但通过UBI检测只有2例呈阳性。同样，33例2型AI-CAH意大利患者中，29例（88%）通过UBI检测抗HCV呈极强阳性，而10例英国患者中无一例呈阳性。AI-CAH意大利患者似乎有很高的真正感染HCV的频率，而英国患者通过Ortho HCV ELISA检测呈血清阳性很可能代表假阳性结果。这些发现表明不同人群中自身免疫性肝病存在重要的地理和/或遗传影响。
