Vincenza Calvaruso, Antonio Craxì, Gastroenterologia and Epatologia, DIBIMIS, Università di Palermo, 90127 Palermo, Italy.
World J Gastroenterol. 2013 Dec 21;19(47):8916-23. doi: 10.3748/wjg.v19.i47.8916.
A higher prevalence of immunological processes has recently been reported in patients with hepatitis C virus (HCV) infection, focusing the attention of physicians and researchers on the close association between HCV and immune disorders. HCV lymphotropism represents the most important step in the pathogenesis of virus-related immunological diseases and experimental, virologic, and clinical evidence has demonstrated a trigger role for HCV both in systemic autoimmune diseases, such as rheumatoid arthritis, Sjögren syndrome, hemolytic anemia and severe thrombocytopenia, and in organ-specific autoimmune diseases, such as autoimmune hepatitis, thyroid disorders and diabetes. This review will outline the principal aspects of such HCV-induced immunological alterations, focusing on the prevalence of these less characterized HCV extrahepatic manifestations.
最近有报道称，丙型肝炎病毒（HCV）感染患者的免疫过程更为普遍，这引起了医生和研究人员的关注，使他们注意到 HCV 与免疫紊乱之间的密切关联。HCV 的淋巴亲嗜性代表了病毒相关免疫性疾病发病机制中的最重要步骤，实验、病毒学和临床证据表明 HCV 既是全身性自身免疫性疾病（如类风湿关节炎、干燥综合征、溶血性贫血和严重血小板减少症）的触发因素，也是器官特异性自身免疫性疾病（如自身免疫性肝炎、甲状腺疾病和糖尿病）的触发因素。本文将概述这种由 HCV 引起的免疫改变的主要方面，重点介绍这些特征尚不明确的 HCV 肝外表现的流行情况。
