Chae C B, Smith M C, Morris H P
Biochem J. 1975 Jan;146(1):281-3. doi: 10.1042/bj1460281.
Proteinase associated with chromatin isolated from liver and hepatoma of rat is stimulated by salt, and, of the histone fractions, lysine-rich (F1) histone is preferentially degraded by this enzyme at an ionic strength comparable with that found in the nucleus. However, there appears to be no strict relationship between the activity of the proteinase and growth rates of hepatomas. Chromatin isolated from a fast-growing tumour, Ehrlich ascites carcinoma, shows no apparent proteinase activity in the presence of salt.
从大鼠肝脏和肝癌中分离出的与染色质相关的蛋白酶受盐刺激，并且在与细胞核中发现的离子强度相当的情况下，在组蛋白组分中，富含赖氨酸的（F1）组蛋白优先被这种酶降解。然而，蛋白酶的活性与肝癌的生长速率之间似乎没有严格的关系。从快速生长的肿瘤艾氏腹水癌中分离出的染色质在有盐存在的情况下未显示出明显的蛋白酶活性。
