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是否应向HIV血清学不一致和血清学一致的伴侣提供抗逆转录病毒治疗:一场伦理讨论?

Should ART be offered to HIV-serodiscordant and HIV-seroconcordant couples: an ethical discussion?

作者信息

Zutlevics Tamara

机构信息

Women's and Children's Hospital, Research Institute, Adelaide, Australia.

出版信息

Hum Reprod. 2006 Aug;21(8):1956-60. doi: 10.1093/humrep/del082. Epub 2006 Jun 13.

DOI:10.1093/humrep/del082
PMID:16772283
Abstract

Increasingly, fertility clinics are offering their services to human immunodeficiency virus (HIV)-serodiscordant couples where the woman is seropositive. In the case of HIV-seroconcordant couples, there remains a general reluctance to provide treatment. This attitude to seroconcordant couples is reminiscent of that once widely held towards serodiscordant couples when the risk of vertical transmission rates in pregnant women was greater than 1-2%. Due to recent advances in HIV clinical care and assisted reproduction technique (ART) procedures directed at reducing the risk of viral transmission during gamete transfer, where good healthcare is available, the current risk rate has fallen to 1-2%. This article deals with the ethical arguments of those who remain opposed to offering HIV-serodiscordant and HIV-seroconcordant couples access to ART. Until these arguments have been addressed, clinics providing ART to such couples cannot be assured that their practices are ethical.

摘要

越来越多的生育诊所开始为女性为血清阳性的人类免疫缺陷病毒(HIV)血清学不一致的夫妇提供服务。对于HIV血清学一致的夫妇,人们普遍仍不愿提供治疗。这种对血清学一致夫妇的态度让人想起曾经对血清学不一致夫妇的普遍态度,当时孕妇垂直传播率高于1%-2%。由于HIV临床护理和辅助生殖技术(ART)程序在降低配子转移期间病毒传播风险方面取得了最新进展,在具备良好医疗保健条件的地方,目前的风险率已降至1%-2%。本文探讨了那些仍然反对为HIV血清学不一致和HIV血清学一致的夫妇提供ART的人的伦理观点。在这些观点得到解决之前,为这类夫妇提供ART的诊所无法确保其做法符合伦理。

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HIV AIDS (Auckl). 2012;4:29-35. doi: 10.2147/HIV.S19413. Epub 2012 Feb 9.
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Women facing HIV. Key question on women with HIV infection: Italian consensus workshop.
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Infection. 2009 Apr;37(2):168-78. doi: 10.1007/s15010-008-7361-7. Epub 2009 Mar 23.