Figiel G S, Krishnan K R, Doraiswamy P M, Nemeroff C B
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110.
J Geriatr Psychiatry Neurol. 1991 Apr-Jun;4(2):86-9. doi: 10.1177/089198879100400206.
Elderly patients are particularly sensitive to the neurologic side effects of psychotropic medications. This increased sensitivity may be related to brain structural changes associated with aging. In this pilot study, the authors report on the occurrence of caudate hyperintensities, using brain magnetic resonance imaging, in seven elderly depressed subjects who developed neuroleptic-induced parkinsonism. Caudate hyperintensities were not observed in any of the seven healthy elderly controls examined. These results suggest that caudate hyperintensities may render some elderly depressed patients susceptible to neuroleptic-induced parkinsonism.
老年患者对精神药物的神经副作用特别敏感。这种敏感性增加可能与衰老相关的脑结构变化有关。在这项初步研究中，作者报告了7名患抗精神病药所致帕金森综合征的老年抑郁症患者经脑磁共振成像检查出现的尾状核高信号情况。在接受检查的7名健康老年对照者中均未观察到尾状核高信号。这些结果表明，尾状核高信号可能使一些老年抑郁症患者易患抗精神病药所致帕金森综合征。
