Bocola V, Fabbrini G, Sollecito A, Paladini C, Martucci N
Casa di Cura Villa Pini D'Abruzzo', Chieti, Italy.
J Neurol Neurosurg Psychiatry. 1996 Feb;60(2):213-6. doi: 10.1136/jnnp.60.2.213.
Parkinsonism is a common complication of neuroleptic drug use; however, the pathophysiology of the persistence of parkinsonian symptoms after withdrawal of neuroleptic drugs is poorly understood. Twenty patients with neuroleptic induced parkinsonism were studied by high field MRI. Persistence of symptoms was associated with different findings depending on the age of the patients--namely, putaminal hypointensity in young patients and striatal hyperintensities in old patients. High field MRI may be useful in identifying patients at higher risk for neuroleptic induced parkinsonism.
帕金森综合征是使用抗精神病药物常见的并发症；然而，抗精神病药物停用后帕金森症状持续存在的病理生理学机制却鲜为人知。对20例抗精神病药物所致帕金森综合征患者进行了高场强磁共振成像（MRI）研究。症状持续存在与不同的表现有关，这取决于患者的年龄——即年轻患者壳核信号减低，老年患者纹状体信号增强。高场强MRI可能有助于识别抗精神病药物所致帕金森综合征风险较高的患者。
